Novel alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

TY - JOUR

T1 - Novel alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

AU - Desrivieres, Sylvane

AU - Chu, Congying

AU - Schumann, Gunter

PY - 2019/6/11

Y1 - 2019/6/11

N2 - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcoholconsumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data and gene expression studies.Our results identify genetic pathways associated with alcohol consumption and suggest shared genetic mechanisms with neuropsychiatric disorders including schizophrenia.

AB - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcoholconsumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data and gene expression studies.Our results identify genetic pathways associated with alcohol consumption and suggest shared genetic mechanisms with neuropsychiatric disorders including schizophrenia.

M3 - Article

SN - 2397-3374

JO - Nature Human Behaviour

JF - Nature Human Behaviour

ER -