Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences

P Nony, J Tessier, G Chadeuf, P Ward, A Giraud, M Dugast, R M Linden, P Moullier, A Salvetti

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45 Citations (Scopus)

Abstract

This study identifies a region of the adeno-associated virus type 2 (AAV-2) rep gene (nucleotides 190 to 540 of wild-type AAV-2) as a cis-acting Rep-dependent element able to promote the replication of transiently transfected plasmids. This viral element is also shown to be involved in the amplification of integrated sequences in the presence of adenovirus and Rep proteins
Original languageEnglish
Pages (from-to)9991 - 9994
Number of pages4
JournalJournal of Virology
Volume75
Issue number20
DOIs
Publication statusPublished - 2001

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