Adams, HHH, Hibar, DP, Chouraki, V, Stein, JL, Nyquist, PA, Rentería, ME, Trompet, S, Arias-vasquez, A, Seshadri, S
, Desrivières, S, Beecham, AH, Jahanshad, N, Wittfeld, K, Van Der Lee, SJ, Abramovic, L, Alhusaini, S, Amin, N, Andersson, M, Arfanakis, K, Aribisala, BS, Armstrong, NJ, Athanasiu, L, Axelsson, T, Beiser, A, Bernard, M, Bis, JC, Blanken, LME, Blanton, SH, Bohlken, MM, Boks, MP, Bralten, J, Brickman, AM, Carmichael, O, Chakravarty, MM, Chauhan, G, Chen, Q, Ching, CRK, Cuellar-partida, G, Braber, AD, Doan, NT, Ehrlich, S, Filippi, I, Ge, T, Giddaluru, S, Goldman, AL, Gottesman, RF
, Greven, CU, Grimm, O, Griswold, ME, Guadalupe, T, Hass, J, Haukvik, UK, Hilal, S, Hofer, E, Hoehn, D, Holmes, AJ, Hoogman, M, Janowitz, D
, Jia, T, Kasperaviciute, D, Kim, S, Klein, M, Kraemer, B, Lee, PH, Liao, J, Liewald, DCM, Lopez, LM, Luciano, M
, Macare, C, Marquand, A, Matarin, M, Mather, KA, Mattheisen, M, Mazoyer, B, Mckay, DR, Mcwhirter, R, Milaneschi, Y, Mirza-schreiber, N, Muetzel, RL, Maniega, SM, Nho, K, Nugent, AC, Loohuis, LMO, Oosterlaan, J, Papmeyer, M, Pappa, I, Pirpamer, L, Pudas, S, Pütz, B, Rajan, KB, Ramasamy, A, Richards, JS, Risacher, SL, Roiz-santiañez, R, Rommelse, N, Rose, EJ, Royle, NA, Rundek, T, Sämann, PG, Satizabal, CL, Schmaal, L, Schork, AJ, Shen, L, Shin, J, Shumskaya, E, Smith, AV, Sprooten, E, Strike, LT, Teumer, A, Thomson, R, Tordesillas-gutierrez, D, Toro, R, Trabzuni, D, Vaidya, D, Van Der Grond, J, Van Der Meer, D, Van Donkelaar, MMJ, Van Eijk, KR, Van Erp, TGM, Van Rooij, D, Walton, E, Westlye, LT, Whelan, CD, Windham, BG, Winkler, AM, Woldehawariat, G, Wolf, C, Wolfers, T
, Xu, B, Yanek, LR, Yang, J, Zijdenbos, A, Zwiers, MP, Agartz, I, Aggarwal, NT, Almasy, L, Ames, D, Amouyel, P, Andreassen, OA, Arepalli, S, Assareh, AA, Barral, S, Bastin, ME, Becker, DM, Becker, JT, Bennett, DA, Blangero, J, Van Bokhoven, H, Boomsma, DI, Brodaty, H, Brouwer, RM, Brunner, HG, Buckner, RL, Buitelaar, JK, Bulayeva, KB, Cahn, W, Calhoun, VD, Cannon, DM, Cavalleri, GL, Chen, C, Cheng, C, Cichon, S, Cookson, MR, Corvin, A, Crespo-facorro, B, Curran, JE, Czisch, M, Dale, AM, Davies, GE, De Geus, EJC, De Jager, PL, De Zubicaray, GI, Delanty, N, Depondt, C, Destefano, AL, Dillman, A, Djurovic, S, Donohoe, G, Drevets, WC, Duggirala, R, Dyer, TD, Erk, S, Espeseth, T, Evans, DA, Fedko, IO, Fernández, G, Ferrucci, L, Fisher, SE, Fleischman, DA, Ford, I, Foroud, TM, Fox, PT, Francks, C, Fukunaga, M, Gibbs, JR, Glahn, DC, Gollub, RL, Göring, HHH, Grabe, HJ, Green, RC, Gruber, O, Gudnason, V, Guelfi, S, Hansell, NK, Hardy, J, Hartman, CA, Hashimoto, R, Hegenscheid, K, Heinz, A, Le Hellard, S, Hernandez, DG, Heslenfeld, DJ, Ho, B, Hoekstra, PJ, Hoffmann, W, Hofman, A, Holsboer, F, Homuth, G, Hosten, N, Hottenga, J, Pol, HEH, Ikeda, M, Ikram, MK, Jack, CR, Jenkinson, M, Johnson, R, Jönsson, EG, Jukema, JW, Kahn, RS, Kanai, R, Kloszewska, I, Knopman, DS, Kochunov, P, Kwok, JB, Lawrie, SM, Lemaître, H, Liu, X, Longo, DL, Longstreth, WT, Lopez, OL
, Lovestone, S, Martinez, O, Martinot, J, Mattay, VS, Mcdonald, C, Mcintosh, AM, Mcmahon, KL, Mcmahon, FJ, Mecocci, P, Melle, I, Meyer-lindenberg, A, Mohnke, S, Montgomery, GW, Morris, DW, Mosley, TH, Mühleisen, TW, Müller-myhsok, B, Nalls, MA, Nauck, M, Nichols, TE, Niessen, WJ, Nöthen, MM, Nyberg, L, Ohi, K, Olvera, RL, Ophoff, RA, Pandolfo, M, Paus, T, Pausova, Z, Penninx, BWJH, Pike, GB, Potkin, SG, Psaty, BM, Reppermund, S, Rietschel, M, Roffman, JL, Romanczuk-seiferth, N, Rotter, JI, Ryten, M, Sacco, RL, Sachdev, PS, Saykin, AJ, Schmidt, R, Schofield, PR, Sigurdsson, S
, Simmons, A, Singleton, A, Sisodiya, SM, Smith, C, Smoller, JW, Soininen, H, Srikanth, V, Steen, VM, Stott, DJ, Sussmann, JE, Thalamuthu, A, Tiemeier, H, Toga, AW, Traynor, BJ, Troncoso, J, Turner, JA, Tzourio, C, Uitterlinden, AG, Hernández, MCV, Van Der Brug, M, Van Der Lugt, A, Van Der Wee, NJA, Van Duijn, CM, Van Haren, NEM, Van ′t Ent, D, Van Tol, M, Vardarajan, BN, Veltman, DJ, Vernooij, MW, Völzke, H, Walter, H, Wardlaw, JM, Wassink, TH
, Weale, ME, Weinberger, DR, Weiner, MW, Wen, W, Westman, E, White, T, Wong, TY, Wright, CB, Zielke, HR, Zonderman, AB, Deary, IJ, Decarli, C, Schmidt, H, Martin, NG, De Craen, AJM, Wright, MJ, Launer, LJ
, Schumann, G, Fornage, M, Franke, B, Debette, S, Medland, SE, Ikram, MA & Thompson, PM 2016, '
Novel genetic loci underlying human intracranial volume identified through genome-wide association',
Nature Neuroscience, vol. 19, no. 12, pp. 1569-1582.
https://doi.org/10.1038/nn.4398Adams, Hieab H H ; Hibar, Derrek P ; Chouraki, Vincent et al. / Novel genetic loci underlying human intracranial volume identified through genome-wide association. In: Nature Neuroscience. 2016 ; Vol. 19, No. 12. pp. 1569-1582.
@article{99aba4ae80d24aa19d30cef2e2efa5ac,
title = "Novel genetic loci underlying human intracranial volume identified through genome-wide association",
abstract = "Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson{\textquoteright}s disease, and enriched near genes involved in growth pathways including PI3K-AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth",
author = "Adams, {Hieab H H} and Hibar, {Derrek P} and Vincent Chouraki and Stein, {Jason L} and Nyquist, {Paul A} and Renter{\'i}a, {Miguel E} and Stella Trompet and Alejandro Arias-vasquez and Sudha Seshadri and Sylvane Desrivi{\`e}res and Beecham, {Ashley H} and Neda Jahanshad and Katharina Wittfeld and {Van Der Lee}, {Sven J} and Lucija Abramovic and Saud Alhusaini and Najaf Amin and Micael Andersson and Konstantinos Arfanakis and Aribisala, {Benjamin S} and Armstrong, {Nicola J} and Lavinia Athanasiu and Tomas Axelsson and Alexa Beiser and Manon Bernard and Bis, {Joshua C} and Blanken, {Laura M E} and Blanton, {Susan H} and Bohlken, {Marc M} and Boks, {Marco P} and Janita Bralten and Brickman, {Adam M} and Owen Carmichael and Chakravarty, {M Mallar} and Ganesh Chauhan and Qiang Chen and Ching, {Christopher R K} and Gabriel Cuellar-partida and Braber, {Anouk Den} and Doan, {Nhat Trung} and Stefan Ehrlich and Irina Filippi and Tian Ge and Sudheer Giddaluru and Goldman, {Aaron L} and Gottesman, {Rebecca F} and Greven, {Corina U} and Oliver Grimm and Griswold, {Michael E} and Tulio Guadalupe and Johanna Hass and Haukvik, {Unn K} and Saima Hilal and Edith Hofer and David Hoehn and Holmes, {Avram J} and Martine Hoogman and Deborah Janowitz and Tianye Jia and Dalia Kasperaviciute and Sungeun Kim and Marieke Klein and Bernd Kraemer and Lee, {Phil H} and Jiemin Liao and Liewald, {David C M} and Lopez, {Lorna M} and Michelle Luciano and Christine Macare and Andre Marquand and Mar Matarin and Mather, {Karen A} and Manuel Mattheisen and Bernard Mazoyer and Mckay, {David R} and Rebekah Mcwhirter and Yuri Milaneschi and Nazanin Mirza-schreiber and Muetzel, {Ryan L} and Maniega, {Susana Mu{\~n}oz} and Kwangsik Nho and Nugent, {Allison C} and Loohuis, {Loes M Olde} and Jaap Oosterlaan and Martina Papmeyer and Irene Pappa and Lukas Pirpamer and Sara Pudas and Benno P{\"u}tz and Rajan, {Kumar B} and Adaikalavan Ramasamy and Richards, {Jennifer S} and Risacher, {Shannon L} and Roberto Roiz-santia{\~n}ez and Nanda Rommelse and Rose, {Emma J} and Royle, {Natalie A} and Tatjana Rundek and S{\"a}mann, {Philipp G} and Satizabal, {Claudia L} and Lianne Schmaal and Schork, {Andrew J} and Li Shen and Jean Shin and Elena Shumskaya and Smith, {Albert V} and Emma Sprooten and Strike, {Lachlan T} and Alexander Teumer and Russell Thomson and Diana Tordesillas-gutierrez and Roberto Toro and Daniah Trabzuni and Dhananjay Vaidya and {Van Der Grond}, Jeroen and {Van Der Meer}, Dennis and {Van Donkelaar}, {Marjolein M J} and {Van Eijk}, {Kristel R} and {Van Erp}, {Theo G M} and {Van Rooij}, Daan and Esther Walton and Westlye, {Lars T} and Whelan, {Christopher D} and Windham, {Beverly G} and Winkler, {Anderson M} and Girma Woldehawariat and Christiane Wolf and Thomas Wolfers and Bing Xu and Yanek, {Lisa R} and Jingyun Yang and Alex Zijdenbos and Zwiers, {Marcel P} and Ingrid Agartz and Aggarwal, {Neelum T} and Laura Almasy and David Ames and Philippe Amouyel and Andreassen, {Ole A} and Sampath Arepalli and Assareh, {Amelia A} and Sandra Barral and Bastin, {Mark E} and Becker, {Diane M} and Becker, {James T} and Bennett, {David A} and John Blangero and {Van Bokhoven}, Hans and Boomsma, {Dorret I} and Henry Brodaty and Brouwer, {Rachel M} and Brunner, {Han G} and Buckner, {Randy L} and Buitelaar, {Jan K} and Bulayeva, {Kazima B} and Wiepke Cahn and Calhoun, {Vince D} and Cannon, {Dara M} and Cavalleri, {Gianpiero L} and Christopher Chen and Ching-yu Cheng and Sven Cichon and Cookson, {Mark R} and Aiden Corvin and Benedicto Crespo-facorro and Curran, {Joanne E} and Michael Czisch and Dale, {Anders M} and Davies, {Gareth E} and {De Geus}, {Eco J C} and {De Jager}, {Philip L} and {De Zubicaray}, {Greig I} and Norman Delanty and Chantal Depondt and Destefano, {Anita L} and Allissa Dillman and Srdjan Djurovic and Gary Donohoe and Drevets, {Wayne C} and Ravi Duggirala and Dyer, {Thomas D} and Susanne Erk and Thomas Espeseth and Evans, {Denis A} and Fedko, {Iryna O} and Guill{\'e}n Fern{\'a}ndez and Luigi Ferrucci and Fisher, {Simon E} and Fleischman, {Debra A} and Ian Ford and Foroud, {Tatiana M} and Fox, {Peter T} and Clyde Francks and Masaki Fukunaga and Gibbs, {J Raphael} and Glahn, {David C} and Gollub, {Randy L} and G{\"o}ring, {Harald H H} and Grabe, {Hans J} and Green, {Robert C} and Oliver Gruber and Vilmundur Gudnason and Sebastian Guelfi and Hansell, {Narelle K} and John Hardy and Hartman, {Catharina A} and Ryota Hashimoto and Katrin Hegenscheid and Andreas Heinz and {Le Hellard}, Stephanie and Hernandez, {Dena G} and Heslenfeld, {Dirk J} and Beng-choon Ho and Hoekstra, {Pieter J} and Wolfgang Hoffmann and Albert Hofman and Florian Holsboer and Georg Homuth and Norbert Hosten and Jouke-jan Hottenga and Pol, {Hilleke E Hulshoff} and Masashi Ikeda and Ikram, {M Kamran} and Jack, {Clifford R} and Mark Jenkinson and Robert Johnson and J{\"o}nsson, {Erik G} and Jukema, {J Wouter} and Kahn, {Ren{\'e} S} and Ryota Kanai and Iwona Kloszewska and Knopman, {David S} and Peter Kochunov and Kwok, {John B} and Lawrie, {Stephen M} and Herv{\'e} Lema{\^i}tre and Xinmin Liu and Longo, {Dan L} and Longstreth, {W T} and Lopez, {Oscar L} and Simon Lovestone and Oliver Martinez and Jean-luc Martinot and Mattay, {Venkata S} and Colm Mcdonald and Mcintosh, {Andrew M} and Mcmahon, {Katie L} and Mcmahon, {Francis J} and Patrizia Mecocci and Ingrid Melle and Andreas Meyer-lindenberg and Sebastian Mohnke and Montgomery, {Grant W} and Morris, {Derek W} and Mosley, {Thomas H} and M{\"u}hleisen, {Thomas W} and Bertram M{\"u}ller-myhsok and Nalls, {Michael A} and Matthias Nauck and Nichols, {Thomas E} and Niessen, {Wiro J} and N{\"o}then, {Markus M} and Lars Nyberg and Kazutaka Ohi and Olvera, {Rene L} and Ophoff, {Roel A} and Massimo Pandolfo and Tomas Paus and Zdenka Pausova and Penninx, {Brenda W J H} and Pike, {G Bruce} and Potkin, {Steven G} and Psaty, {Bruce M} and Simone Reppermund and Marcella Rietschel and Roffman, {Joshua L} and Nina Romanczuk-seiferth and Rotter, {Jerome I} and Mina Ryten and Sacco, {Ralph L} and Sachdev, {Perminder S} and Saykin, {Andrew J} and Reinhold Schmidt and Schofield, {Peter R} and Sigurdur Sigurdsson and Andy Simmons and Andrew Singleton and Sisodiya, {Sanjay M} and Colin Smith and Smoller, {Jordan W} and Hilkka Soininen and Velandai Srikanth and Steen, {Vidar M} and Stott, {David J} and Sussmann, {Jessika E} and Anbupalam Thalamuthu and Henning Tiemeier and Toga, {Arthur W} and Traynor, {Bryan J} and Juan Troncoso and Turner, {Jessica A} and Christophe Tzourio and Uitterlinden, {Andre G} and Hern{\'a}ndez, {Maria C Vald{\'e}s} and {Van Der Brug}, Marcel and {Van Der Lugt}, Aad and {Van Der Wee}, {Nic J A} and {Van Duijn}, {Cornelia M} and {Van Haren}, {Neeltje E M} and {Van ′t Ent}, Dennis and {Van Tol}, Marie-jose and Vardarajan, {Badri N} and Veltman, {Dick J} and Vernooij, {Meike W} and Henry V{\"o}lzke and Henrik Walter and Wardlaw, {Joanna M} and Wassink, {Thomas H} and Weale, {Michael E} and Weinberger, {Daniel R} and Weiner, {Michael W} and Wei Wen and Eric Westman and Tonya White and Wong, {Tien Y} and Wright, {Clinton B} and Zielke, {H Ronald} and Zonderman, {Alan B} and Deary, {Ian J} and Charles Decarli and Helena Schmidt and Martin, {Nicholas G} and {De Craen}, {Anton J M} and Wright, {Margaret J} and Launer, {Lenore J} and Gunter Schumann and Myriam Fornage and Barbara Franke and St{\'e}phanie Debette and Medland, {Sarah E} and Ikram, {M Arfan} and Thompson, {Paul M}",
year = "2016",
month = dec,
day = "31",
doi = "10.1038/nn.4398",
language = "English",
volume = "19",
pages = "1569--1582",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}
TY - JOUR
T1 - Novel genetic loci underlying human intracranial volume identified through genome-wide association
AU - Adams, Hieab H H
AU - Hibar, Derrek P
AU - Chouraki, Vincent
AU - Stein, Jason L
AU - Nyquist, Paul A
AU - Rentería, Miguel E
AU - Trompet, Stella
AU - Arias-vasquez, Alejandro
AU - Seshadri, Sudha
AU - Desrivières, Sylvane
AU - Beecham, Ashley H
AU - Jahanshad, Neda
AU - Wittfeld, Katharina
AU - Van Der Lee, Sven J
AU - Abramovic, Lucija
AU - Alhusaini, Saud
AU - Amin, Najaf
AU - Andersson, Micael
AU - Arfanakis, Konstantinos
AU - Aribisala, Benjamin S
AU - Armstrong, Nicola J
AU - Athanasiu, Lavinia
AU - Axelsson, Tomas
AU - Beiser, Alexa
AU - Bernard, Manon
AU - Bis, Joshua C
AU - Blanken, Laura M E
AU - Blanton, Susan H
AU - Bohlken, Marc M
AU - Boks, Marco P
AU - Bralten, Janita
AU - Brickman, Adam M
AU - Carmichael, Owen
AU - Chakravarty, M Mallar
AU - Chauhan, Ganesh
AU - Chen, Qiang
AU - Ching, Christopher R K
AU - Cuellar-partida, Gabriel
AU - Braber, Anouk Den
AU - Doan, Nhat Trung
AU - Ehrlich, Stefan
AU - Filippi, Irina
AU - Ge, Tian
AU - Giddaluru, Sudheer
AU - Goldman, Aaron L
AU - Gottesman, Rebecca F
AU - Greven, Corina U
AU - Grimm, Oliver
AU - Griswold, Michael E
AU - Guadalupe, Tulio
AU - Hass, Johanna
AU - Haukvik, Unn K
AU - Hilal, Saima
AU - Hofer, Edith
AU - Hoehn, David
AU - Holmes, Avram J
AU - Hoogman, Martine
AU - Janowitz, Deborah
AU - Jia, Tianye
AU - Kasperaviciute, Dalia
AU - Kim, Sungeun
AU - Klein, Marieke
AU - Kraemer, Bernd
AU - Lee, Phil H
AU - Liao, Jiemin
AU - Liewald, David C M
AU - Lopez, Lorna M
AU - Luciano, Michelle
AU - Macare, Christine
AU - Marquand, Andre
AU - Matarin, Mar
AU - Mather, Karen A
AU - Mattheisen, Manuel
AU - Mazoyer, Bernard
AU - Mckay, David R
AU - Mcwhirter, Rebekah
AU - Milaneschi, Yuri
AU - Mirza-schreiber, Nazanin
AU - Muetzel, Ryan L
AU - Maniega, Susana Muñoz
AU - Nho, Kwangsik
AU - Nugent, Allison C
AU - Loohuis, Loes M Olde
AU - Oosterlaan, Jaap
AU - Papmeyer, Martina
AU - Pappa, Irene
AU - Pirpamer, Lukas
AU - Pudas, Sara
AU - Pütz, Benno
AU - Rajan, Kumar B
AU - Ramasamy, Adaikalavan
AU - Richards, Jennifer S
AU - Risacher, Shannon L
AU - Roiz-santiañez, Roberto
AU - Rommelse, Nanda
AU - Rose, Emma J
AU - Royle, Natalie A
AU - Rundek, Tatjana
AU - Sämann, Philipp G
AU - Satizabal, Claudia L
AU - Schmaal, Lianne
AU - Schork, Andrew J
AU - Shen, Li
AU - Shin, Jean
AU - Shumskaya, Elena
AU - Smith, Albert V
AU - Sprooten, Emma
AU - Strike, Lachlan T
AU - Teumer, Alexander
AU - Thomson, Russell
AU - Tordesillas-gutierrez, Diana
AU - Toro, Roberto
AU - Trabzuni, Daniah
AU - Vaidya, Dhananjay
AU - Van Der Grond, Jeroen
AU - Van Der Meer, Dennis
AU - Van Donkelaar, Marjolein M J
AU - Van Eijk, Kristel R
AU - Van Erp, Theo G M
AU - Van Rooij, Daan
AU - Walton, Esther
AU - Westlye, Lars T
AU - Whelan, Christopher D
AU - Windham, Beverly G
AU - Winkler, Anderson M
AU - Woldehawariat, Girma
AU - Wolf, Christiane
AU - Wolfers, Thomas
AU - Xu, Bing
AU - Yanek, Lisa R
AU - Yang, Jingyun
AU - Zijdenbos, Alex
AU - Zwiers, Marcel P
AU - Agartz, Ingrid
AU - Aggarwal, Neelum T
AU - Almasy, Laura
AU - Ames, David
AU - Amouyel, Philippe
AU - Andreassen, Ole A
AU - Arepalli, Sampath
AU - Assareh, Amelia A
AU - Barral, Sandra
AU - Bastin, Mark E
AU - Becker, Diane M
AU - Becker, James T
AU - Bennett, David A
AU - Blangero, John
AU - Van Bokhoven, Hans
AU - Boomsma, Dorret I
AU - Brodaty, Henry
AU - Brouwer, Rachel M
AU - Brunner, Han G
AU - Buckner, Randy L
AU - Buitelaar, Jan K
AU - Bulayeva, Kazima B
AU - Cahn, Wiepke
AU - Calhoun, Vince D
AU - Cannon, Dara M
AU - Cavalleri, Gianpiero L
AU - Chen, Christopher
AU - Cheng, Ching-yu
AU - Cichon, Sven
AU - Cookson, Mark R
AU - Corvin, Aiden
AU - Crespo-facorro, Benedicto
AU - Curran, Joanne E
AU - Czisch, Michael
AU - Dale, Anders M
AU - Davies, Gareth E
AU - De Geus, Eco J C
AU - De Jager, Philip L
AU - De Zubicaray, Greig I
AU - Delanty, Norman
AU - Depondt, Chantal
AU - Destefano, Anita L
AU - Dillman, Allissa
AU - Djurovic, Srdjan
AU - Donohoe, Gary
AU - Drevets, Wayne C
AU - Duggirala, Ravi
AU - Dyer, Thomas D
AU - Erk, Susanne
AU - Espeseth, Thomas
AU - Evans, Denis A
AU - Fedko, Iryna O
AU - Fernández, Guillén
AU - Ferrucci, Luigi
AU - Fisher, Simon E
AU - Fleischman, Debra A
AU - Ford, Ian
AU - Foroud, Tatiana M
AU - Fox, Peter T
AU - Francks, Clyde
AU - Fukunaga, Masaki
AU - Gibbs, J Raphael
AU - Glahn, David C
AU - Gollub, Randy L
AU - Göring, Harald H H
AU - Grabe, Hans J
AU - Green, Robert C
AU - Gruber, Oliver
AU - Gudnason, Vilmundur
AU - Guelfi, Sebastian
AU - Hansell, Narelle K
AU - Hardy, John
AU - Hartman, Catharina A
AU - Hashimoto, Ryota
AU - Hegenscheid, Katrin
AU - Heinz, Andreas
AU - Le Hellard, Stephanie
AU - Hernandez, Dena G
AU - Heslenfeld, Dirk J
AU - Ho, Beng-choon
AU - Hoekstra, Pieter J
AU - Hoffmann, Wolfgang
AU - Hofman, Albert
AU - Holsboer, Florian
AU - Homuth, Georg
AU - Hosten, Norbert
AU - Hottenga, Jouke-jan
AU - Pol, Hilleke E Hulshoff
AU - Ikeda, Masashi
AU - Ikram, M Kamran
AU - Jack, Clifford R
AU - Jenkinson, Mark
AU - Johnson, Robert
AU - Jönsson, Erik G
AU - Jukema, J Wouter
AU - Kahn, René S
AU - Kanai, Ryota
AU - Kloszewska, Iwona
AU - Knopman, David S
AU - Kochunov, Peter
AU - Kwok, John B
AU - Lawrie, Stephen M
AU - Lemaître, Hervé
AU - Liu, Xinmin
AU - Longo, Dan L
AU - Longstreth, W T
AU - Lopez, Oscar L
AU - Lovestone, Simon
AU - Martinez, Oliver
AU - Martinot, Jean-luc
AU - Mattay, Venkata S
AU - Mcdonald, Colm
AU - Mcintosh, Andrew M
AU - Mcmahon, Katie L
AU - Mcmahon, Francis J
AU - Mecocci, Patrizia
AU - Melle, Ingrid
AU - Meyer-lindenberg, Andreas
AU - Mohnke, Sebastian
AU - Montgomery, Grant W
AU - Morris, Derek W
AU - Mosley, Thomas H
AU - Mühleisen, Thomas W
AU - Müller-myhsok, Bertram
AU - Nalls, Michael A
AU - Nauck, Matthias
AU - Nichols, Thomas E
AU - Niessen, Wiro J
AU - Nöthen, Markus M
AU - Nyberg, Lars
AU - Ohi, Kazutaka
AU - Olvera, Rene L
AU - Ophoff, Roel A
AU - Pandolfo, Massimo
AU - Paus, Tomas
AU - Pausova, Zdenka
AU - Penninx, Brenda W J H
AU - Pike, G Bruce
AU - Potkin, Steven G
AU - Psaty, Bruce M
AU - Reppermund, Simone
AU - Rietschel, Marcella
AU - Roffman, Joshua L
AU - Romanczuk-seiferth, Nina
AU - Rotter, Jerome I
AU - Ryten, Mina
AU - Sacco, Ralph L
AU - Sachdev, Perminder S
AU - Saykin, Andrew J
AU - Schmidt, Reinhold
AU - Schofield, Peter R
AU - Sigurdsson, Sigurdur
AU - Simmons, Andy
AU - Singleton, Andrew
AU - Sisodiya, Sanjay M
AU - Smith, Colin
AU - Smoller, Jordan W
AU - Soininen, Hilkka
AU - Srikanth, Velandai
AU - Steen, Vidar M
AU - Stott, David J
AU - Sussmann, Jessika E
AU - Thalamuthu, Anbupalam
AU - Tiemeier, Henning
AU - Toga, Arthur W
AU - Traynor, Bryan J
AU - Troncoso, Juan
AU - Turner, Jessica A
AU - Tzourio, Christophe
AU - Uitterlinden, Andre G
AU - Hernández, Maria C Valdés
AU - Van Der Brug, Marcel
AU - Van Der Lugt, Aad
AU - Van Der Wee, Nic J A
AU - Van Duijn, Cornelia M
AU - Van Haren, Neeltje E M
AU - Van ′t Ent, Dennis
AU - Van Tol, Marie-jose
AU - Vardarajan, Badri N
AU - Veltman, Dick J
AU - Vernooij, Meike W
AU - Völzke, Henry
AU - Walter, Henrik
AU - Wardlaw, Joanna M
AU - Wassink, Thomas H
AU - Weale, Michael E
AU - Weinberger, Daniel R
AU - Weiner, Michael W
AU - Wen, Wei
AU - Westman, Eric
AU - White, Tonya
AU - Wong, Tien Y
AU - Wright, Clinton B
AU - Zielke, H Ronald
AU - Zonderman, Alan B
AU - Deary, Ian J
AU - Decarli, Charles
AU - Schmidt, Helena
AU - Martin, Nicholas G
AU - De Craen, Anton J M
AU - Wright, Margaret J
AU - Launer, Lenore J
AU - Schumann, Gunter
AU - Fornage, Myriam
AU - Franke, Barbara
AU - Debette, Stéphanie
AU - Medland, Sarah E
AU - Ikram, M Arfan
AU - Thompson, Paul M
PY - 2016/12/31
Y1 - 2016/12/31
N2 - Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K-AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth
AB - Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K-AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth
U2 - 10.1038/nn.4398
DO - 10.1038/nn.4398
M3 - Article
VL - 19
SP - 1569
EP - 1582
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 12
ER -