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Novel myosin-based therapies for congenital cardiac and skeletal myopathies

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages4
JournalJournal of Medical Genetics
Early online date13 Jul 2016
DOIs
StateE-pub ahead of print - 13 Jul 2016

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King's Authors

Abstract

The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.

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