Novel techniques for sentinel lymph node biopsy in breast cancer: a systematic review

Muneer Ahmed, Arnie D. Purushotham, Michael Douek*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

260 Citations (Scopus)

Abstract

The existing standard for axillary lymph node staging in breast cancer patients with a clinically and radiologically normal axilla is sentinel lymph node biopsy with a radioisotope and blue dye (dual technique). The dependence on radioisotopes means that uptake of the procedure is limited to only about 60% of eligible patients in developed countries and is negligible elsewhere. We did a systematic review to assess three techniques for sentinel lymph node biopsy that are not radioisotope dependent or that refine the existing method: indocyanine green fluorescence, contrast-enhanced ultrasound using microbubbles, and superparamagnetic iron oxide nanoparticles. Our systematic review suggested that these new methods for sentinel lymph node biopsy have clinical potential but give high levels of false-negative results. We could not identify any technique that challenged the existing standard procedure. Further assessment of these techniques against the standard dual technique in randomised trials is needed.

Original languageEnglish
Pages (from-to)e351-e362
Number of pages12
JournalThe Lancet Oncology
Volume15
Issue number8
DOIs
Publication statusPublished - Jul 2014

Keywords

  • INDOCYANINE GREEN FLUORESCENCE
  • CONTRAST-ENHANCED ULTRASOUND
  • CELL LUNG-CANCER
  • CLINICAL-TRIALS
  • PATENT BLUE
  • IDENTIFICATION
  • METAANALYSIS
  • MICROBUBBLES
  • LOCALIZATION
  • MULTICENTER

Fingerprint

Dive into the research topics of 'Novel techniques for sentinel lymph node biopsy in breast cancer: a systematic review'. Together they form a unique fingerprint.

Cite this