Nox4 is dispensable for exercise induced muscle fibre switch

Juri Vogel; Flávia Figueiredo De Rezende; Susanne Rohrbach; Min Zhang; Katrin Schröder

doi:10.1371/journal.pone.0130769

Nox4 is dispensable for exercise induced muscle fibre switch

Juri Vogel, Flávia Figueiredo De Rezende, Susanne Rohrbach, Min Zhang, Katrin Schröder

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Introduction: By producing H₂O₂, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal. Here we hypothesized that Nox4 contributes to exercise-induced adaptation such as changes in muscle metabolism or muscle fibre specification and studied this in wildtype and Nox4-/- mice. Results: Exercise, as induced by voluntary running in a running wheel or forced running on a tread-mill induced a switch from fast twitch to intermediate fibres. However the induced muscle fibre switch was similar between Nox4-/- and wildtype mice. The same held true for exercise-induced expression of PGC1α or AMPK activation. Both are increased in response to exercise, but with no difference was observed between wildtype and Nox4-/- mice. Conclusion: Thus, exercise-induced muscle fibre switch is Nox4-independent.

Original language	English
Article number	e0130769
Journal	PL o S One
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0130769
Publication status	Published - 17 Jun 2015

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abstract = "Introduction: By producing H2O2, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal. Here we hypothesized that Nox4 contributes to exercise-induced adaptation such as changes in muscle metabolism or muscle fibre specification and studied this in wildtype and Nox4-/- mice. Results: Exercise, as induced by voluntary running in a running wheel or forced running on a tread-mill induced a switch from fast twitch to intermediate fibres. However the induced muscle fibre switch was similar between Nox4-/- and wildtype mice. The same held true for exercise-induced expression of PGC1α or AMPK activation. Both are increased in response to exercise, but with no difference was observed between wildtype and Nox4-/- mice. Conclusion: Thus, exercise-induced muscle fibre switch is Nox4-independent.",

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AU - Vogel, Juri

AU - De Rezende, Flávia Figueiredo

AU - Rohrbach, Susanne

AU - Zhang, Min

AU - Schröder, Katrin

PY - 2015/6/17

Y1 - 2015/6/17

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Nox4 is dispensable for exercise induced muscle fibre switch

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