Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation

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28 Citations (Scopus)

Abstract

Nuclear receptor signalling is essential for physiological processes such as metabolism, development, and reproduction. Alterations in the endocrine state that naturally occur during pregnancy result in maternal adaptations to support the feto-placental unit. A series of studies have shown that nuclear receptor signalling is involved in maternal adaptations of bile acid, cholesterol, and lipid homeostasis pathways to ensure maintenance of the nutritional demands of the fetus. We discuss regulation of hepatic nuclear receptors and their target genes in pregnancy and their impact on the development of disorders such as intrahepatic cholestasis of pregnancy and oestrogen-induced hepatotoxicity. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
Original languageEnglish
Pages (from-to)879-887
Number of pages9
JournalBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume1812
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Animals
  • Receptors, Cytoplasmic and Nuclear
  • Estrogens
  • Humans
  • Gene Expression
  • Mice
  • Pregnancy
  • Circadian Rhythm
  • Bile Acids and Salts
  • Liver
  • Female
  • Lipid Metabolism
  • Signal Transduction

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