TY - CHAP
T1 - Nuclear Receptors in Pregnancy and Outcomes
T2 - Clinical Perspective
AU - Borges Manna, Luiza
AU - Williamson, Catherine
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Pregnancy is characterised by profound hormonal and metabolic changes in the mother. Both oestrogen and progesterone, along with their respective nuclear receptors, have an important role in maintaining a healthy pregnancy. Equally, other nuclear receptors such as LXR, FXR and the PPARs play important roles in the gradual alterations in metabolism that ensure survival of mother and fetus. Disruptions in nuclear receptor signalling can result in pregnancy disorders such as gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, hypertensive disorders of pregnancy and preterm labour, all of which have both immediate and long-term implications for maternal and fetal health. By reviewing data from human studies and animal models, this chapter will describe the contribution of nuclear receptors to normal pregnancy, their role in gestational disorders and their potential as therapeutic targets.
AB - Pregnancy is characterised by profound hormonal and metabolic changes in the mother. Both oestrogen and progesterone, along with their respective nuclear receptors, have an important role in maintaining a healthy pregnancy. Equally, other nuclear receptors such as LXR, FXR and the PPARs play important roles in the gradual alterations in metabolism that ensure survival of mother and fetus. Disruptions in nuclear receptor signalling can result in pregnancy disorders such as gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, hypertensive disorders of pregnancy and preterm labour, all of which have both immediate and long-term implications for maternal and fetal health. By reviewing data from human studies and animal models, this chapter will describe the contribution of nuclear receptors to normal pregnancy, their role in gestational disorders and their potential as therapeutic targets.
KW - Cholestasis
KW - FXR
KW - Gestational diabetes
KW - Hypertension
KW - LXR
KW - Oestrogen
KW - PPAR
KW - Pregnancy
KW - Progesterone
UR - http://www.scopus.com/inward/record.url?scp=85137894809&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-11836-4_1
DO - 10.1007/978-3-031-11836-4_1
M3 - Chapter
C2 - 36107310
AN - SCOPUS:85137894809
T3 - Advances in Experimental Medicine and Biology
SP - 3
EP - 19
BT - Advances in Experimental Medicine and Biology
PB - SPRINGER
ER -