Nutritional ketosis increases NAD+/NADH ratio in healthy human brain: an in vivo study by 31P-MRS

TY - JOUR

T1 - Nutritional ketosis increases NAD+/NADH ratio in healthy human brain

T2 - an in vivo study by 31P-MRS

AU - Xin, L.

AU - Ipek, Ozlem

AU - Beaumont, M.

AU - Shevlyakova, M.

AU - Christinat, N.

AU - Masoodi, M.

AU - Greenberg, N.

AU - Gruetter, R.

AU - Cuenoud, B.

PY - 2018/7/12

Y1 - 2018/7/12

N2 - Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.

AB - Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.

U2 - 10.3389/fnut.2018.00062

DO - 10.3389/fnut.2018.00062

M3 - Article

SN - 2296-861X

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

ER -