TY - JOUR
T1 - Obesity increases precision errors in total body dual-energy x-ray absorptiometry measurements
AU - Knapp, Karen M.
AU - Welsman, Joanne R.
AU - Hopkins, Susan J.
AU - Shallcross, Andrew
AU - Fogelman, Ignac
AU - Blake, Glen M.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Total body (TB) dual-energy X-ray absorptiometry (DXA) is increasingly being used to measure body composition in research and clinical settings. This study investigated the effect of body mass index (BMI) and body fat on precision errors for total and regional TB DXA measurements of bone mineral density, fat tissue, and lean tissue using the GE Lunar Prodigy (GE Healthcare, Bedford, UK). One hundred forty-four women with BMI's ranging from 18.5 to 45.9kg/m2 were recruited. Participants had duplicate DXA scans of the TB with repositioning between examinations. Participants were divided into 3 groups based on their BMI, and the root mean square standard deviation and the percentage coefficient of variation were calculated for each group. The root mean square standard deviation (percentage coefficient of variation) for the normal (<25kg/m2; n=76), overweight (25-30kg/m2; n=36), and obese (>30kg/m2; n=32) BMI groups, respectively, were total BMD (g/cm2): 0.009 (0.77%), 0.009 (0.69%), 0.011 (0.91%); total fat (g): 545 (2.98%), 486 (1.72%), 677 (1.55%); total lean (g): 551 (1.42%), 540 (1.34%), and 781 (1.68%). These results suggest that serial measurements in obese subjects should be treated with caution because the least significant change may be larger than anticipated.
AB - Total body (TB) dual-energy X-ray absorptiometry (DXA) is increasingly being used to measure body composition in research and clinical settings. This study investigated the effect of body mass index (BMI) and body fat on precision errors for total and regional TB DXA measurements of bone mineral density, fat tissue, and lean tissue using the GE Lunar Prodigy (GE Healthcare, Bedford, UK). One hundred forty-four women with BMI's ranging from 18.5 to 45.9kg/m2 were recruited. Participants had duplicate DXA scans of the TB with repositioning between examinations. Participants were divided into 3 groups based on their BMI, and the root mean square standard deviation and the percentage coefficient of variation were calculated for each group. The root mean square standard deviation (percentage coefficient of variation) for the normal (<25kg/m2; n=76), overweight (25-30kg/m2; n=36), and obese (>30kg/m2; n=32) BMI groups, respectively, were total BMD (g/cm2): 0.009 (0.77%), 0.009 (0.69%), 0.011 (0.91%); total fat (g): 545 (2.98%), 486 (1.72%), 677 (1.55%); total lean (g): 551 (1.42%), 540 (1.34%), and 781 (1.68%). These results suggest that serial measurements in obese subjects should be treated with caution because the least significant change may be larger than anticipated.
KW - Bone mineral density
KW - Dual-energy X-ray absorptiometry
KW - Obesity
KW - Precision
UR - http://www.scopus.com/inward/record.url?scp=84928769832&partnerID=8YFLogxK
U2 - 10.1016/j.jocd.2014.06.001
DO - 10.1016/j.jocd.2014.06.001
M3 - Article
C2 - 25087044
AN - SCOPUS:84928769832
SN - 1094-6950
VL - 18
SP - 209
EP - 216
JO - JOURNAL OF CLINICAL DENSITOMETRY
JF - JOURNAL OF CLINICAL DENSITOMETRY
IS - 2
ER -
