Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes

S E Kahn, B Zinman, S M Haffner, M C O'Neill, B G Kravitz, D H Yu, M I Freed, W H Herman, R R Holman, N P Jones, J M Lachin, G C Viberti

Research output: Contribution to journalArticlepeer-review

152 Citations (Scopus)

Abstract

The inflammatory factor C-reactive protein (CRP) and the fibrinolytic variables fibrinogen and plasminogen activator-1 (PAI-1) are associated with long-term cardiovascular morbidity. To determine the contribution of body adiposity (BMI), insulin sensitivity (homeostasis model assessment of insulin resistance [HOMA-IR], and glycemia (HbA(1c) [A1C]) to the levels of these inflammatory and fibrinolytic variables in recently diagnosed (
Original languageEnglish
Pages (from-to)2357 - 2364
Number of pages8
JournalDiabetes
Volume55
Issue number8
DOIs
Publication statusPublished - Aug 2006

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