King's College London

Research portal

Obesity Surgery and Cancer: What Are the Unanswered Questions?

Research output: Contribution to journalReview article

Standard

Obesity Surgery and Cancer : What Are the Unanswered Questions? / Castagneto-Gissey, Lidia; Casella-Mariolo, James; Casella, Giovanni; Mingrone, Geltrude.

In: Frontiers in Endocrinology , Vol. 11, 213, 15.04.2020.

Research output: Contribution to journalReview article

Harvard

Castagneto-Gissey, L, Casella-Mariolo, J, Casella, G & Mingrone, G 2020, 'Obesity Surgery and Cancer: What Are the Unanswered Questions?', Frontiers in Endocrinology , vol. 11, 213. https://doi.org/10.3389/fendo.2020.00213

APA

Castagneto-Gissey, L., Casella-Mariolo, J., Casella, G., & Mingrone, G. (2020). Obesity Surgery and Cancer: What Are the Unanswered Questions? Frontiers in Endocrinology , 11, [213]. https://doi.org/10.3389/fendo.2020.00213

Vancouver

Castagneto-Gissey L, Casella-Mariolo J, Casella G, Mingrone G. Obesity Surgery and Cancer: What Are the Unanswered Questions? Frontiers in Endocrinology . 2020 Apr 15;11. 213. https://doi.org/10.3389/fendo.2020.00213

Author

Castagneto-Gissey, Lidia ; Casella-Mariolo, James ; Casella, Giovanni ; Mingrone, Geltrude. / Obesity Surgery and Cancer : What Are the Unanswered Questions?. In: Frontiers in Endocrinology . 2020 ; Vol. 11.

Bibtex Download

@article{ed04177bc27e4b2cbb4ba41652d04841,
title = "Obesity Surgery and Cancer: What Are the Unanswered Questions?",
abstract = "Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associated metabolic and cardiovascular disorders. However, the understanding of whether and how bariatric surgery determines a reduction in cancer risk is limited. Obesity-related malignancies primarily include colorectal and hormone-sensitive (endometrium, breast, prostate) cancers. Additionally, esophago-gastric tumors are growing to be recognized as a new category mainly associated with post-bariatric surgery outcomes. In fact, certain types of surgical procedures have been described to induce the development and subsequent progression of pre-cancerous esophageal and gastric lesions. This emerging category is of great concern and further research is required to possibly prevent such risks. Published data has generated conflicting results. In fact, while overall cancer risk reduction was reported particularly in women, some authors showed no improvement or even increased cancer incidence. Although various studies have reported beneficial effects of surgery on risk of specific cancer development, fundamental insights into the pathogenesis of obesity-related cancer are indispensable to fully elucidate its mechanisms.",
keywords = "bariatric surgery, cancer incidence, gastroesophageal cancer, hormone-sensitive cancer, mortality",
author = "Lidia Castagneto-Gissey and James Casella-Mariolo and Giovanni Casella and Geltrude Mingrone",
year = "2020",
month = apr,
day = "15",
doi = "10.3389/fendo.2020.00213",
language = "English",
volume = "11",
journal = "Frontiers in Endocrinology ",
issn = "1664-2392",
publisher = "Frontiers Media S.A.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Obesity Surgery and Cancer

T2 - What Are the Unanswered Questions?

AU - Castagneto-Gissey, Lidia

AU - Casella-Mariolo, James

AU - Casella, Giovanni

AU - Mingrone, Geltrude

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associated metabolic and cardiovascular disorders. However, the understanding of whether and how bariatric surgery determines a reduction in cancer risk is limited. Obesity-related malignancies primarily include colorectal and hormone-sensitive (endometrium, breast, prostate) cancers. Additionally, esophago-gastric tumors are growing to be recognized as a new category mainly associated with post-bariatric surgery outcomes. In fact, certain types of surgical procedures have been described to induce the development and subsequent progression of pre-cancerous esophageal and gastric lesions. This emerging category is of great concern and further research is required to possibly prevent such risks. Published data has generated conflicting results. In fact, while overall cancer risk reduction was reported particularly in women, some authors showed no improvement or even increased cancer incidence. Although various studies have reported beneficial effects of surgery on risk of specific cancer development, fundamental insights into the pathogenesis of obesity-related cancer are indispensable to fully elucidate its mechanisms.

AB - Obesity has become a global epidemic with a soaring economic encumbrance due to its related morbidity and mortality. Amongst obesity-related conditions, cancer is indeed the most redoubtable. Bariatric surgery has been proven to be the most effective treatment for obesity and its associated metabolic and cardiovascular disorders. However, the understanding of whether and how bariatric surgery determines a reduction in cancer risk is limited. Obesity-related malignancies primarily include colorectal and hormone-sensitive (endometrium, breast, prostate) cancers. Additionally, esophago-gastric tumors are growing to be recognized as a new category mainly associated with post-bariatric surgery outcomes. In fact, certain types of surgical procedures have been described to induce the development and subsequent progression of pre-cancerous esophageal and gastric lesions. This emerging category is of great concern and further research is required to possibly prevent such risks. Published data has generated conflicting results. In fact, while overall cancer risk reduction was reported particularly in women, some authors showed no improvement or even increased cancer incidence. Although various studies have reported beneficial effects of surgery on risk of specific cancer development, fundamental insights into the pathogenesis of obesity-related cancer are indispensable to fully elucidate its mechanisms.

KW - bariatric surgery

KW - cancer incidence

KW - gastroesophageal cancer

KW - hormone-sensitive cancer

KW - mortality

UR - http://www.scopus.com/inward/record.url?scp=85083982737&partnerID=8YFLogxK

U2 - 10.3389/fendo.2020.00213

DO - 10.3389/fendo.2020.00213

M3 - Review article

AN - SCOPUS:85083982737

VL - 11

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 213

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454