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Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease

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Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease. / Chappell, Sally; Patel, Tulsi; Guetta-Baranes, Tamar; Sang, Fei; Francis, Paul T.; Morgan, Kevin; Brookes, Keeley J.

In: BMC Research Notes, Vol. 11, No. 1, 646, 04.09.2018.

Research output: Contribution to journalArticle

Harvard

Chappell, S, Patel, T, Guetta-Baranes, T, Sang, F, Francis, PT, Morgan, K & Brookes, KJ 2018, 'Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease', BMC Research Notes, vol. 11, no. 1, 646. https://doi.org/10.1186/s13104-018-3732-8

APA

Chappell, S., Patel, T., Guetta-Baranes, T., Sang, F., Francis, P. T., Morgan, K., & Brookes, K. J. (2018). Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease. BMC Research Notes, 11(1), [646]. https://doi.org/10.1186/s13104-018-3732-8

Vancouver

Chappell S, Patel T, Guetta-Baranes T, Sang F, Francis PT, Morgan K et al. Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease. BMC Research Notes. 2018 Sep 4;11(1). 646. https://doi.org/10.1186/s13104-018-3732-8

Author

Chappell, Sally ; Patel, Tulsi ; Guetta-Baranes, Tamar ; Sang, Fei ; Francis, Paul T. ; Morgan, Kevin ; Brookes, Keeley J. / Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease. In: BMC Research Notes. 2018 ; Vol. 11, No. 1.

Bibtex Download

@article{71260776a7ac4659b46810222f5e6938,
title = "Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease",
abstract = "Objectives: In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how differences between tissue types might inform tissue choice for investigation of altered expression in disease state. The aim of this pilot project was to use RNA-sequencing to investigate gene expression differences between five general areas of post-mortem human brain (frontal, temporal, occipital, parietal and cerebellum), and in particular changes in gene expression in the cerebellum compared to cortex regions for genes relevant to Alzheimer's disease, as the cerebellum is largely preserved from disease pathology and could be an area of interest for neuroprotective pathways. Results: General gene expression profiles were found to be similar between cortical regions of the brain, however the cerebellum presented a distinct expression profile. Focused exploration of gene expression for genes associated with Alzheimer's disease suggest that those involved in the immunity pathway show little expression in the brain. Furthermore some Alzheimer's disease associated genes display significantly different expression in the cerebellum compared with other brain regions, which might indicate potential neuroprotective measures.",
keywords = "Alzheimer's disease, Cerebellum, Human brain, RNA-sequence",
author = "Sally Chappell and Tulsi Patel and Tamar Guetta-Baranes and Fei Sang and Francis, {Paul T.} and Kevin Morgan and Brookes, {Keeley J.}",
year = "2018",
month = "9",
day = "4",
doi = "10.1186/s13104-018-3732-8",
language = "English",
volume = "11",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "BioMed Central",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer's disease

AU - Chappell, Sally

AU - Patel, Tulsi

AU - Guetta-Baranes, Tamar

AU - Sang, Fei

AU - Francis, Paul T.

AU - Morgan, Kevin

AU - Brookes, Keeley J.

PY - 2018/9/4

Y1 - 2018/9/4

N2 - Objectives: In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how differences between tissue types might inform tissue choice for investigation of altered expression in disease state. The aim of this pilot project was to use RNA-sequencing to investigate gene expression differences between five general areas of post-mortem human brain (frontal, temporal, occipital, parietal and cerebellum), and in particular changes in gene expression in the cerebellum compared to cortex regions for genes relevant to Alzheimer's disease, as the cerebellum is largely preserved from disease pathology and could be an area of interest for neuroprotective pathways. Results: General gene expression profiles were found to be similar between cortical regions of the brain, however the cerebellum presented a distinct expression profile. Focused exploration of gene expression for genes associated with Alzheimer's disease suggest that those involved in the immunity pathway show little expression in the brain. Furthermore some Alzheimer's disease associated genes display significantly different expression in the cerebellum compared with other brain regions, which might indicate potential neuroprotective measures.

AB - Objectives: In order to determine how gene expression is altered in disease it is of fundamental importance that the global distribution of gene expression levels across the disease-free brain are understood and how differences between tissue types might inform tissue choice for investigation of altered expression in disease state. The aim of this pilot project was to use RNA-sequencing to investigate gene expression differences between five general areas of post-mortem human brain (frontal, temporal, occipital, parietal and cerebellum), and in particular changes in gene expression in the cerebellum compared to cortex regions for genes relevant to Alzheimer's disease, as the cerebellum is largely preserved from disease pathology and could be an area of interest for neuroprotective pathways. Results: General gene expression profiles were found to be similar between cortical regions of the brain, however the cerebellum presented a distinct expression profile. Focused exploration of gene expression for genes associated with Alzheimer's disease suggest that those involved in the immunity pathway show little expression in the brain. Furthermore some Alzheimer's disease associated genes display significantly different expression in the cerebellum compared with other brain regions, which might indicate potential neuroprotective measures.

KW - Alzheimer's disease

KW - Cerebellum

KW - Human brain

KW - RNA-sequence

UR - http://www.scopus.com/inward/record.url?scp=85053152824&partnerID=8YFLogxK

U2 - 10.1186/s13104-018-3732-8

DO - 10.1186/s13104-018-3732-8

M3 - Article

AN - SCOPUS:85053152824

VL - 11

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

IS - 1

M1 - 646

ER -

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