Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us?

TY - JOUR

T1 - Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder

T2 - What Does Self-Report with the OCI-R Tell Us?

AU - Cadman, Tim

AU - Spain, Debbie

AU - Johnston, Patrick

AU - Russell, Ailsa

AU - Mataix-Cols, David

AU - Craig, Michael

AU - Deeley, Quinton

AU - Robertson, Dene

AU - Murphy, Clodagh

AU - Gillan, Nicola

AU - Wilson, C. Ellie

AU - Mendez, Maria

AU - Ecker, Christine

AU - Daly, Eileen

AU - Findon, James

AU - Glaser, Karen

AU - Bolton, P. F.

AU - Johnston, P.

AU - Mullins, D.

AU - Pasco, G.

AU - Spain, D.

AU - MRC AIMS consortium

AU - Happé, Francesca

AU - Murphy, Declan

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD+OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n=171), OCD (n=108), ASD+OCD (n=54) and control participants (n=92) completed the OCI-R. Individuals with ASD+OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD+versus -OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population.

AB - Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD+OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n=171), OCD (n=108), ASD+OCD (n=54) and control participants (n=92) completed the OCI-R. Individuals with ASD+OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD+versus -OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population.

KW - Adults

KW - Autism spectrum disorder

KW - Hoarding

KW - Obsessive compulsive disorder

KW - Obsessive-compulsive inventory-revised

KW - Self-report questionnaire

UR - http://www.scopus.com/inward/record.url?scp=84941247443&partnerID=8YFLogxK

U2 - 10.1002/aur.1461

DO - 10.1002/aur.1461

M3 - Article

AN - SCOPUS:84941247443

SN - 1939-3792

VL - 8

SP - 477

EP - 485

JO - Autism research

JF - Autism research

IS - 5

ER -