Oestrogen, cognition and the maturing female brain

TY - JOUR

T1 - Oestrogen, cognition and the maturing female brain

AU - Craig, M C

AU - Murphy, D G

PY - 2007/1

Y1 - 2007/1

N2 - Many women complain of memory and other cognitive difficulties at times that are associated with changes in ovarian steroid levels. However, the biological mechanisms through which ovarian steroids exert these effects remains poorly understood. Furthermore, the effect of hormone therapy, especially oestrogen therapy, on cognition and brain function in healthy women, and its role in the prevention of Alzheimer's disease, remains controversial. Here, we review the evidence that, in healthy women, ovarian steroids/oestrogen affects brain regions crucial to higher cognitive function at the macroscopic, microscopic, functional and neurotransmitter levels

AB - Many women complain of memory and other cognitive difficulties at times that are associated with changes in ovarian steroid levels. However, the biological mechanisms through which ovarian steroids exert these effects remains poorly understood. Furthermore, the effect of hormone therapy, especially oestrogen therapy, on cognition and brain function in healthy women, and its role in the prevention of Alzheimer's disease, remains controversial. Here, we review the evidence that, in healthy women, ovarian steroids/oestrogen affects brain regions crucial to higher cognitive function at the macroscopic, microscopic, functional and neurotransmitter levels

U2 - 10.1111/j.1365-2826.2006.01500.x

DO - 10.1111/j.1365-2826.2006.01500.x

M3 - Literature review

VL - 19

SP - 1

EP - 6

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

IS - 1

ER -