Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

L. A. Vaira; C. Hopkins; A. Sandison; A. Manca; N. MacHouchas; D. Turilli; J. R. Lechien; M. R. Barillari; G. Salzano; A. Cossu; S. Saussez; G. De Riu

doi:10.1017/S0022215120002455

Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

L. A. Vaira^*, C. Hopkins, A. Sandison, A. Manca, N. MacHouchas, D. Turilli, J. R. Lechien, M. R. Barillari, G. Salzano, A. Cossu, S. Saussez, G. De Riu

^*Corresponding author for this work

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Abstract

Background. Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. Case report. This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. Conclusion. The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.

Original language	English
Journal	Journal of Laryngology and Otology
DOIs	https://doi.org/10.1017/S0022215120002455
Publication status	Accepted/In press - 2020

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title = "Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia",

abstract = "Background. Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. Case report. This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. Conclusion. The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.",

author = "Vaira, {L. A.} and C. Hopkins and A. Sandison and A. Manca and N. MacHouchas and D. Turilli and Lechien, {J. R.} and Barillari, {M. R.} and G. Salzano and A. Cossu and S. Saussez and {De Riu}, G.",

year = "2020",

doi = "10.1017/S0022215120002455",

language = "English",

journal = "Journal of Laryngology and Otology",

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T1 - Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

AU - Vaira, L. A.

AU - Hopkins, C.

AU - Sandison, A.

AU - Manca, A.

AU - MacHouchas, N.

AU - Turilli, D.

AU - Lechien, J. R.

AU - Barillari, M. R.

AU - Salzano, G.

AU - Cossu, A.

AU - Saussez, S.

AU - De Riu, G.

PY - 2020

Y1 - 2020

N2 - Background. Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. Case report. This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. Conclusion. The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.

AB - Background. Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. Case report. This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. Conclusion. The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.

UR - http://www.scopus.com/inward/record.url?scp=85096459911&partnerID=8YFLogxK

U2 - 10.1017/S0022215120002455

DO - 10.1017/S0022215120002455

M3 - Article

C2 - 33190655

AN - SCOPUS:85096459911

SN - 0022-2151

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

ER -

Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

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