Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia

L. A. Vaira*, C. Hopkins, A. Sandison, A. Manca, N. MacHouchas, D. Turilli, J. R. Lechien, M. R. Barillari, G. Salzano, A. Cossu, S. Saussez, G. De Riu

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    65 Citations (Scopus)

    Abstract

    Background. Olfactory dysfunction represents one of the most frequent symptoms of coronavirus disease 2019, affecting about 70 per cent of patients. However, the pathogenesis of the olfactory dysfunction in coronavirus disease 2019 has not yet been elucidated. Case report. This report presents the radiological and histopathological findings of a patient who presented with anosmia persisting for more than three months after infection with severe acute respiratory syndrome coronavirus-2. Conclusion. The biopsy demonstrated significant disruption of the olfactory epithelium. This shifts the focus away from invasion of the olfactory bulb and encourages further studies of treatments targeted at the surface epithelium.

    Original languageEnglish
    JournalJournal of Laryngology and Otology
    DOIs
    Publication statusAccepted/In press - 2020

    Fingerprint

    Dive into the research topics of 'Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia'. Together they form a unique fingerprint.

    Cite this