TY - JOUR
T1 - Omalizumab in IgE-Mediated Food Allergy
T2 - A Systematic Review and Meta-Analysis
AU - Zuberbier, Torsten
AU - Wood, Robert A.
AU - Bindslev-Jensen, Carsten
AU - Fiocchi, Alessandro
AU - Chinthrajah, R. Sharon
AU - Worm, Margitta
AU - Deschildre, Antoine
AU - Fernandez-Rivas, Montserrat
AU - Santos, Alexandra F.
AU - Jaumont, Xavier
AU - Tassinari, Paolo
N1 - Funding Information:
The authors thank Asma S, PhD, Ali Nasir Siddiqui, PhD, Sagar Prakash Wagh, MPharm, Ian Wright, PhD, and Samantha Baneham, MPharm (Novartis) for providing medical writing/editorial support, which was funded by Novartis, in accordance with Good Publication Practice (GPP3) guidelines ( http://www.ismpp.org/gpp3 ). The authors also acknowledge Molecular Connections Pvt Ltd for providing support in data analyses.
Publisher Copyright:
© 2022 The Authors
PY - 2023/4
Y1 - 2023/4
N2 - Background: A growing number of studies have shown encouraging results with omalizumab (OMA) as monotherapy and as an adjunct to oral immunotherapy (OMA+OIT) in patients with single/multiple food allergies. Objectives: To evaluate the efficacy and safety of OMA or OMA+OIT in patients with immunoglobulin E (IgE)–mediated food allergy. Methods: An extensive literature search (inception to December 31, 2020) was performed to identify randomized, controlled, and observational studies that assessed OMA as monotherapy or OMA+OIT in patients with IgE-mediated food allergy. The outcomes were an increase in tolerated dose of foods, successful desensitization, sustained unresponsiveness, immunological biomarkers, severity of allergic reactions to food, quality of life (QoL), and safety. A P less than .05 was considered significant. Results: In total, 36 studies were included. The OMA monotherapy (vs pre-OMA) significantly increased the tolerated dose of multiple foods; increased the threshold of tolerated dose for milk, egg, wheat, and baked milk; improved QoL; and reduced food-induced allergic reactions (all P < .01). The OMA+OIT significantly increased the tolerated dose of multiple foods (vs placebo and pre-OMA), desensitization (vs placebo+OIT and pre-OMA) (all P ≤ .01), and improved QoL (vs pre-OMA) and immunoglobulin G4 levels (both P < .01). No major safety concerns were identified. Conclusions: In IgE-mediated food allergy, OMA can help patients consume multiple foods and allow for food dose escalation. As an adjunct to OIT, OMA can also support high-dose desensitization and higher maintenance doses. Further studies are warranted to empirically evaluate the effect of OMA and confirm these findings.
AB - Background: A growing number of studies have shown encouraging results with omalizumab (OMA) as monotherapy and as an adjunct to oral immunotherapy (OMA+OIT) in patients with single/multiple food allergies. Objectives: To evaluate the efficacy and safety of OMA or OMA+OIT in patients with immunoglobulin E (IgE)–mediated food allergy. Methods: An extensive literature search (inception to December 31, 2020) was performed to identify randomized, controlled, and observational studies that assessed OMA as monotherapy or OMA+OIT in patients with IgE-mediated food allergy. The outcomes were an increase in tolerated dose of foods, successful desensitization, sustained unresponsiveness, immunological biomarkers, severity of allergic reactions to food, quality of life (QoL), and safety. A P less than .05 was considered significant. Results: In total, 36 studies were included. The OMA monotherapy (vs pre-OMA) significantly increased the tolerated dose of multiple foods; increased the threshold of tolerated dose for milk, egg, wheat, and baked milk; improved QoL; and reduced food-induced allergic reactions (all P < .01). The OMA+OIT significantly increased the tolerated dose of multiple foods (vs placebo and pre-OMA), desensitization (vs placebo+OIT and pre-OMA) (all P ≤ .01), and improved QoL (vs pre-OMA) and immunoglobulin G4 levels (both P < .01). No major safety concerns were identified. Conclusions: In IgE-mediated food allergy, OMA can help patients consume multiple foods and allow for food dose escalation. As an adjunct to OIT, OMA can also support high-dose desensitization and higher maintenance doses. Further studies are warranted to empirically evaluate the effect of OMA and confirm these findings.
KW - Desensitization
KW - Food (allergen) tolerance
KW - IgE-mediated food allergy
KW - Meta-analysis
KW - Omalizumab
KW - Oral immunotherapy
KW - Sustained unresponsiveness
UR - http://www.scopus.com/inward/record.url?scp=85149879950&partnerID=8YFLogxK
U2 - 10.1016/j.jaip.2022.11.036
DO - 10.1016/j.jaip.2022.11.036
M3 - Article
C2 - 36529441
AN - SCOPUS:85149879950
SN - 2213-2198
VL - 11
SP - 1134
EP - 1146
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 4
ER -