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Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder

Research output: Contribution to journalArticle

Rachel V Gow, Frederic Vallee-Tourangeau, Michael Angus Crawford, Eric Taylor, Kebreab Ghebremeskel, Allain A Bueno, Joseph R Hibbeln, Alexander Sumich, Katya Rubia

Original languageEnglish
Pages (from-to)411-8
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume88
Issue number6
DOIs
PublishedJun 2013

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.

King's Authors

Abstract

A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n-3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, male children with (n=29) and without a clinical diagnosis of ADHD (n=43) were compared in their plasma levels of LC-PUFA. Plasma DHA was higher in the control group prior to statistical correction. Callous-unemotional (CU) traits were found to be significantly negatively related to both eicosapentaenoic acid (EPA), and total omega-3 in the ADHD group. The findings unveil for the first time that CU and anti-social traits in ADHD are associated with lower omega-3 levels.

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