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Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

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Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. / Menni, Cristina; Zierer, Jonas; Pallister, Tess; Jackson, Matthew A.; Long, Tao; Mohney, Robert P.; Steves, Claire J.; Spector, Tim D.; Valdes, Ana M.

In: Scientific Reports, Vol. 7, No. 1, 11079, 11.09.2017.

Research output: Contribution to journalArticle

Harvard

Menni, C, Zierer, J, Pallister, T, Jackson, MA, Long, T, Mohney, RP, Steves, CJ, Spector, TD & Valdes, AM 2017, 'Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women', Scientific Reports, vol. 7, no. 1, 11079. https://doi.org/10.1038/s41598-017-10382-2

APA

Menni, C., Zierer, J., Pallister, T., Jackson, M. A., Long, T., Mohney, R. P., ... Valdes, A. M. (2017). Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Scientific Reports, 7(1), [11079]. https://doi.org/10.1038/s41598-017-10382-2

Vancouver

Menni C, Zierer J, Pallister T, Jackson MA, Long T, Mohney RP et al. Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Scientific Reports. 2017 Sep 11;7(1). 11079. https://doi.org/10.1038/s41598-017-10382-2

Author

Menni, Cristina ; Zierer, Jonas ; Pallister, Tess ; Jackson, Matthew A. ; Long, Tao ; Mohney, Robert P. ; Steves, Claire J. ; Spector, Tim D. ; Valdes, Ana M. / Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. In: Scientific Reports. 2017 ; Vol. 7, No. 1.

Bibtex Download

@article{5f272911c9e8460ba7c7776dd32818d9,
title = "Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women",
abstract = "Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10(-7)). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.",
keywords = "Journal Article",
author = "Cristina Menni and Jonas Zierer and Tess Pallister and Jackson, {Matthew A.} and Tao Long and Mohney, {Robert P.} and Steves, {Claire J.} and Spector, {Tim D.} and Valdes, {Ana M.}",
year = "2017",
month = "9",
day = "11",
doi = "10.1038/s41598-017-10382-2",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women

AU - Menni, Cristina

AU - Zierer, Jonas

AU - Pallister, Tess

AU - Jackson, Matthew A.

AU - Long, Tao

AU - Mohney, Robert P.

AU - Steves, Claire J.

AU - Spector, Tim D.

AU - Valdes, Ana M.

PY - 2017/9/11

Y1 - 2017/9/11

N2 - Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10(-7)). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.

AB - Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10(-7)). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85029293821&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-10382-2

DO - 10.1038/s41598-017-10382-2

M3 - Article

C2 - 28894110

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 11079

ER -

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