Omics technologies and the study of human ageing

Ana M. Valdes; Daniel Glass; Tim D. Spector

doi:10.1038/nrg3553

Omics technologies and the study of human ageing

Ana M. Valdes^*, Daniel Glass, Tim D. Spector

^*Corresponding author for this work

Twin Research & Genetic Epidemiology

Research output: Contribution to journal › Literature review › peer-review

95 Citations (Scopus)

Abstract

Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age.

Original language	English
Article number	N/A
Pages (from-to)	601-607
Number of pages	7
Journal	NATURE REVIEWS GENETICS
Volume	14
Issue number	9
DOIs	https://doi.org/10.1038/nrg3553
Publication status	Published - Sept 2013

Keywords

DETECTABLE CLONAL MOSAICISM
DNA METHYLATION
HUMAN BRAIN
HUMAN LONGEVITY
GENOME
AGE
CANCER
HETEROPLASMY
ASSOCIATION
POPULATION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrg3553

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title = "Omics technologies and the study of human ageing",

abstract = "Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age.",

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AU - Valdes, Ana M.

AU - Glass, Daniel

AU - Spector, Tim D.

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N2 - Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age.

AB - Normal ageing is associated with diverse physiological changes in all organ systems but the rate and extent of these changes vary markedly among individuals. One aspect of ageing research focuses on the molecular profiling of the changes that occur with increasing age in humans. Such profiling has implications for disease prevention and treatment. New high-throughput 'omics' technologies (such as genomics, metabolomics, metagenomics and transcriptomics) are enabling detailed studies of these molecular changes and are thus revealing information about the biological pathways that change with age.

KW - DETECTABLE CLONAL MOSAICISM

KW - DNA METHYLATION

KW - HUMAN BRAIN

KW - HUMAN LONGEVITY

KW - GENOME

KW - AGE

KW - CANCER

KW - HETEROPLASMY

KW - ASSOCIATION

KW - POPULATION

U2 - 10.1038/nrg3553

DO - 10.1038/nrg3553

M3 - Literature review

SN - 1471-0056

VL - 14

SP - 601

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JO - NATURE REVIEWS GENETICS

JF - NATURE REVIEWS GENETICS

IS - 9

M1 - N/A

ER -

Omics technologies and the study of human ageing

Abstract

Keywords

UN SDGs

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