On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [18F]FDG radiotracer

Mark D. Tarn; Anri Isu; Stephen J. Archibald; Nicole Pamme

On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer

Mark D. Tarn, Anri Isu, Stephen J. Archibald, Nicole Pamme^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

7 Citations (Scopus)

Abstract

We present on-chip absorbance-based determination of pH and optical clarity for quality control (QC) testing of 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG), a positron emission tomography (PET) radiotracer. The platform allows fast analysis times, reduces radioactive exposure to personnel, and requires only minimal sample volumes, making it suitable for dose-on-demand radiotracer synthesis.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	1077-1079
Number of pages	3
ISBN (Electronic)	9780979806476
Publication status	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/2014 → 30/10/2014

Keywords

Absorbance spectroscopy
Optical clarity
PH determination
Positron emission tomography (PET)
Quality control
[F]FDG

Cite this

Tarn, M. D., Isu, A., Archibald, S. J., & Pamme, N. (2014). On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1077-1079). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Tarn, Mark D. ; Isu, Anri ; Archibald, Stephen J. et al. / On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 1077-1079 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

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title = "On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [18F]FDG radiotracer",

abstract = "We present on-chip absorbance-based determination of pH and optical clarity for quality control (QC) testing of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), a positron emission tomography (PET) radiotracer. The platform allows fast analysis times, reduces radioactive exposure to personnel, and requires only minimal sample volumes, making it suitable for dose-on-demand radiotracer synthesis.",

keywords = "Absorbance spectroscopy, Optical clarity, PH determination, Positron emission tomography (PET), Quality control, [F]FDG",

author = "Tarn, {Mark D.} and Anri Isu and Archibald, {Stephen J.} and Nicole Pamme",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "English",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "1077--1079",

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Tarn, MD, Isu, A, Archibald, SJ & Pamme, N 2014, On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 1077-1079, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 26/10/2014.

On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer. / Tarn, Mark D.; Isu, Anri; Archibald, Stephen J. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1077-1079 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

TY - CHAP

T1 - On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [18F]FDG radiotracer

AU - Tarn, Mark D.

AU - Isu, Anri

AU - Archibald, Stephen J.

AU - Pamme, Nicole

N1 - Publisher Copyright: © 14CBMS.

PY - 2014

Y1 - 2014

N2 - We present on-chip absorbance-based determination of pH and optical clarity for quality control (QC) testing of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), a positron emission tomography (PET) radiotracer. The platform allows fast analysis times, reduces radioactive exposure to personnel, and requires only minimal sample volumes, making it suitable for dose-on-demand radiotracer synthesis.

AB - We present on-chip absorbance-based determination of pH and optical clarity for quality control (QC) testing of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), a positron emission tomography (PET) radiotracer. The platform allows fast analysis times, reduces radioactive exposure to personnel, and requires only minimal sample volumes, making it suitable for dose-on-demand radiotracer synthesis.

KW - Absorbance spectroscopy

KW - Optical clarity

KW - PH determination

KW - Positron emission tomography (PET)

KW - Quality control

KW - [F]FDG

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M3 - Conference paper

AN - SCOPUS:84941661794

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

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BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Tarn MD, Isu A, Archibald SJ, Pamme N. On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 1077-1079. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).