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On the role of ephrinA2 in auditory function

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On the role of ephrinA2 in auditory function. / Ingham, Neil J.; Steel, Karen P.; Drescher, Uwe.

In: Hearing Research, Vol. 350, 07.2017, p. 11-16.

Research output: Contribution to journalArticle

Harvard

Ingham, NJ, Steel, KP & Drescher, U 2017, 'On the role of ephrinA2 in auditory function', Hearing Research, vol. 350, pp. 11-16. https://doi.org/10.1016/j.heares.2017.04.002

APA

Ingham, N. J., Steel, K. P., & Drescher, U. (2017). On the role of ephrinA2 in auditory function. Hearing Research, 350, 11-16. https://doi.org/10.1016/j.heares.2017.04.002

Vancouver

Ingham NJ, Steel KP, Drescher U. On the role of ephrinA2 in auditory function. Hearing Research. 2017 Jul;350:11-16. https://doi.org/10.1016/j.heares.2017.04.002

Author

Ingham, Neil J. ; Steel, Karen P. ; Drescher, Uwe. / On the role of ephrinA2 in auditory function. In: Hearing Research. 2017 ; Vol. 350. pp. 11-16.

Bibtex Download

@article{ba945e1ba3364e7ca1f23119485d0e92,
title = "On the role of ephrinA2 in auditory function",
abstract = "Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings. However, we found that ephrinA2 knockout mice had auditory threshold sensitivity for click and 3–42 kHz tone pip frequencies comparable to that of their wildtype littermates. Evoked potential wave amplitudes, latencies and inter-peak intervals were also comparable between ephrinA2 knockout mice and wild type control littermates. Thus in our experiments we could not replicate the findings of Yates et al. (2014). Whilst the EphA/ephrinA system may therefore play a role in the development of innervation of the cochlea and neural circuitry of the auditory brainstem, there appears to be a functional redundancy between members of this family such that loss of ephrinA2 function alone is insufficient to alter auditory function in the mouse.",
keywords = "Auditory brainstem response, Evoked potentials, Mouse, EphA/ephrinA, Hearing thresholds, Auditory system",
author = "Ingham, {Neil J.} and Steel, {Karen P.} and Uwe Drescher",
year = "2017",
month = jul,
doi = "10.1016/j.heares.2017.04.002",
language = "English",
volume = "350",
pages = "11--16",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - On the role of ephrinA2 in auditory function

AU - Ingham, Neil J.

AU - Steel, Karen P.

AU - Drescher, Uwe

PY - 2017/7

Y1 - 2017/7

N2 - Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings. However, we found that ephrinA2 knockout mice had auditory threshold sensitivity for click and 3–42 kHz tone pip frequencies comparable to that of their wildtype littermates. Evoked potential wave amplitudes, latencies and inter-peak intervals were also comparable between ephrinA2 knockout mice and wild type control littermates. Thus in our experiments we could not replicate the findings of Yates et al. (2014). Whilst the EphA/ephrinA system may therefore play a role in the development of innervation of the cochlea and neural circuitry of the auditory brainstem, there appears to be a functional redundancy between members of this family such that loss of ephrinA2 function alone is insufficient to alter auditory function in the mouse.

AB - Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings. However, we found that ephrinA2 knockout mice had auditory threshold sensitivity for click and 3–42 kHz tone pip frequencies comparable to that of their wildtype littermates. Evoked potential wave amplitudes, latencies and inter-peak intervals were also comparable between ephrinA2 knockout mice and wild type control littermates. Thus in our experiments we could not replicate the findings of Yates et al. (2014). Whilst the EphA/ephrinA system may therefore play a role in the development of innervation of the cochlea and neural circuitry of the auditory brainstem, there appears to be a functional redundancy between members of this family such that loss of ephrinA2 function alone is insufficient to alter auditory function in the mouse.

KW - Auditory brainstem response

KW - Evoked potentials

KW - Mouse

KW - EphA/ephrinA

KW - Hearing thresholds

KW - Auditory system

U2 - 10.1016/j.heares.2017.04.002

DO - 10.1016/j.heares.2017.04.002

M3 - Article

VL - 350

SP - 11

EP - 16

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

ER -

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