TY - JOUR
T1 - One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation
AU - Brännström, Mats
AU - Bokström, Hans
AU - Dahm-Kähler, Pernilla
AU - Diaz-Garcia, Cesar
AU - Ekberg, Jana
AU - Enskog, Anders
AU - Hagberg, Henrik
AU - Johannesson, Liza
AU - Kvarnström, Niclas
AU - Mölne, Johan
AU - Olausson, Michael
AU - Olofsson, Jan I.
AU - Rodriguez-Wallberg, Kenny
PY - 2016/4/25
Y1 - 2016/4/25
N2 - Objective To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Design Part of an observational study. Setting XXX. Patient(s) Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s) In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s) Results of IVF-ET, parameters of pregnancy/birth, and surgical data of cesarean section/hysterectomy. Result(s) Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal–vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 2.5 years after UTx. Conclusion(s) This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. Clinical Trial Registration NCT01844362.
AB - Objective To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Design Part of an observational study. Setting XXX. Patient(s) Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s) In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s) Results of IVF-ET, parameters of pregnancy/birth, and surgical data of cesarean section/hysterectomy. Result(s) Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal–vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 2.5 years after UTx. Conclusion(s) This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. Clinical Trial Registration NCT01844362.
KW - Human
KW - infertility
KW - pregnancy
KW - transplantation
KW - uterus
U2 - 10.1016/j.fertnstert.2016.04.001
DO - 10.1016/j.fertnstert.2016.04.001
M3 - Article
SN - 0015-0282
JO - Fertility and Sterility
JF - Fertility and Sterility
ER -