Onset time of topical analgesia with EMLA 5%: No reduction with glyceryl trinitrate

MR Nott; CJ Clemson; JL Peacock

Onset time of topical analgesia with EMLA 5%: No reduction with glyceryl trinitrate

MR Nott^*, CJ Clemson, JL Peacock

^*Corresponding author for this work

Population Health Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P=0.01).

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	European Journal of Anaesthesiology
Volume	13
Issue number	1
Publication status	Published - Jan 1996

Keywords

anaesthetics local, EMLA cream
pain, experimental
pharmacology, glyceryl trinitrate
LIDOCAINE-PRILOCAINE CREAM
VENOUS CANNULATION
LOCAL-ANESTHESIA
VENIPUNCTURE
PAIN
INJECTION
MORPHINE

Cite this

@article{43418248923c4a3984de2175360520cc,

title = "Onset time of topical analgesia with EMLA 5%: No reduction with glyceryl trinitrate",

abstract = "Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P=0.01).",

keywords = "anaesthetics local, EMLA cream, pain, experimental, pharmacology, glyceryl trinitrate, LIDOCAINE-PRILOCAINE CREAM, VENOUS CANNULATION, LOCAL-ANESTHESIA, VENIPUNCTURE, PAIN, INJECTION, MORPHINE",

author = "MR Nott and CJ Clemson and JL Peacock",

year = "1996",

month = jan,

language = "English",

volume = "13",

pages = "17--20",

journal = "European Journal of Anaesthesiology",

issn = "0265-0215",

publisher = "Wolters Kluwer Health",

number = "1",

}

TY - JOUR

T1 - Onset time of topical analgesia with EMLA 5%: No reduction with glyceryl trinitrate

AU - Nott, MR

AU - Clemson, CJ

AU - Peacock, JL

PY - 1996/1

Y1 - 1996/1

N2 - Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P=0.01).

AB - Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P=0.01).

KW - anaesthetics local, EMLA cream

KW - pain, experimental

KW - pharmacology, glyceryl trinitrate

KW - LIDOCAINE-PRILOCAINE CREAM

KW - VENOUS CANNULATION

KW - LOCAL-ANESTHESIA

KW - VENIPUNCTURE

KW - PAIN

KW - INJECTION

KW - MORPHINE

M3 - Article

SN - 0265-0215

VL - 13

SP - 17

EP - 20

JO - European Journal of Anaesthesiology

JF - European Journal of Anaesthesiology

IS - 1

ER -

Onset time of topical analgesia with EMLA 5%: No reduction with glyceryl trinitrate

Abstract

Keywords

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