TY - JOUR
T1 - Opicapone and Levodopa-Carbidopa Intestinal Gel Infusion
T2 - The Way Forward Towards Cost Savings for Healthcare Systems?
AU - Leta, Valentina
AU - van Wamelen, Daniel J.
AU - Sauerbier, Anna
AU - Jones, Shelley
AU - Parry, Miriam
AU - Rizos, Alexandra
AU - Chaudhuri, K. Ray
PY - 2020
Y1 - 2020
N2 - Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson's disease (PD) patients on LCIG with concomitant Opicapone. In 11 patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05) without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of £142,820.63/year in the United Kingdom while maintaining clinical care.
AB - Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson's disease (PD) patients on LCIG with concomitant Opicapone. In 11 patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05) without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of £142,820.63/year in the United Kingdom while maintaining clinical care.
KW - Catechol-O-methyl-transferase-inhibitor
KW - cost savings
KW - intrajejunal Levodopa infusion
KW - Levodopa-Carbidopa intestinal gel
KW - Opicapone
UR - http://www.scopus.com/inward/record.url?scp=85095461286&partnerID=8YFLogxK
U2 - 10.3233/JPD-202022
DO - 10.3233/JPD-202022
M3 - Article
C2 - 32597817
AN - SCOPUS:85095461286
SN - 1877-7171
VL - 10
SP - 1535
EP - 1539
JO - Journal of Parkinson's Disease
JF - Journal of Parkinson's Disease
IS - 4
ER -