Opioid imaging

Alexander Hammers; Anne Lingford-Hughes

doi:10.1016/j.nic.2006.06.004

Opioid imaging

Alexander Hammers^*, Anne Lingford-Hughes

^*Corresponding author for this work

PET Imaging Centre Facility

Research output: Contribution to journal › Literature review › peer-review

20 Citations (Scopus)

Abstract

Many breakthrough scientific discoveries have been made using opioid imaging, particularly in the fields of pain, addiction and epilepsy research. Recent developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand binding, and large-scale statistical analysis of imaging datasets. Suitable single-photon emission computed tomography (SPECT) tracers are lacking, but with the increase in the number of available PET (or PET/CT) cameras and cyclotrons thanks to the clinical successes of PET in oncology, PET may become widespread enough to overcome this limitation. In the coming decade, we hope to see a more widespread application of the techniques developed in healthy volunteers to patients and more clinical impact of opioid imaging.

Original language	English
Pages (from-to)	529-552
Number of pages	24
Journal	Neuroimaging Clinics of North America
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.nic.2006.06.004
Publication status	Published - Nov 2006

Keywords

POSITRON-EMISSION-TOMOGRAPHY
TEMPORAL-LOBE EPILEPSY
OPIATE-RECEPTOR-BINDING
HEROIN-DEPENDENT VOLUNTEERS
MESSENGER-RNA EXPRESSION
HUMAN-BRAIN
IN-VIVO
C-11 DIPRENORPHINE
ALZHEIMERS-DISEASE
RAT-BRAIN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nic.2006.06.004

Cite this

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title = "Opioid imaging",

abstract = "Many breakthrough scientific discoveries have been made using opioid imaging, particularly in the fields of pain, addiction and epilepsy research. Recent developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand binding, and large-scale statistical analysis of imaging datasets. Suitable single-photon emission computed tomography (SPECT) tracers are lacking, but with the increase in the number of available PET (or PET/CT) cameras and cyclotrons thanks to the clinical successes of PET in oncology, PET may become widespread enough to overcome this limitation. In the coming decade, we hope to see a more widespread application of the techniques developed in healthy volunteers to patients and more clinical impact of opioid imaging.",

keywords = "POSITRON-EMISSION-TOMOGRAPHY, TEMPORAL-LOBE EPILEPSY, OPIATE-RECEPTOR-BINDING, HEROIN-DEPENDENT VOLUNTEERS, MESSENGER-RNA EXPRESSION, HUMAN-BRAIN, IN-VIVO, C-11 DIPRENORPHINE, ALZHEIMERS-DISEASE, RAT-BRAIN",

author = "Alexander Hammers and Anne Lingford-Hughes",

year = "2006",

month = nov,

doi = "10.1016/j.nic.2006.06.004",

language = "English",

volume = "16",

pages = "529--552",

journal = "Neuroimaging Clinics of North America",

issn = "1052-5149",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Opioid imaging

AU - Hammers, Alexander

AU - Lingford-Hughes, Anne

PY - 2006/11

Y1 - 2006/11

N2 - Many breakthrough scientific discoveries have been made using opioid imaging, particularly in the fields of pain, addiction and epilepsy research. Recent developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand binding, and large-scale statistical analysis of imaging datasets. Suitable single-photon emission computed tomography (SPECT) tracers are lacking, but with the increase in the number of available PET (or PET/CT) cameras and cyclotrons thanks to the clinical successes of PET in oncology, PET may become widespread enough to overcome this limitation. In the coming decade, we hope to see a more widespread application of the techniques developed in healthy volunteers to patients and more clinical impact of opioid imaging.

AB - Many breakthrough scientific discoveries have been made using opioid imaging, particularly in the fields of pain, addiction and epilepsy research. Recent developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand binding, and large-scale statistical analysis of imaging datasets. Suitable single-photon emission computed tomography (SPECT) tracers are lacking, but with the increase in the number of available PET (or PET/CT) cameras and cyclotrons thanks to the clinical successes of PET in oncology, PET may become widespread enough to overcome this limitation. In the coming decade, we hope to see a more widespread application of the techniques developed in healthy volunteers to patients and more clinical impact of opioid imaging.

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - TEMPORAL-LOBE EPILEPSY

KW - OPIATE-RECEPTOR-BINDING

KW - HEROIN-DEPENDENT VOLUNTEERS

KW - MESSENGER-RNA EXPRESSION

KW - HUMAN-BRAIN

KW - IN-VIVO

KW - C-11 DIPRENORPHINE

KW - ALZHEIMERS-DISEASE

KW - RAT-BRAIN

U2 - 10.1016/j.nic.2006.06.004

DO - 10.1016/j.nic.2006.06.004

M3 - Literature review

SN - 1052-5149

VL - 16

SP - 529

EP - 552

JO - Neuroimaging Clinics of North America

JF - Neuroimaging Clinics of North America

IS - 4

ER -

Opioid imaging

Abstract

Keywords

UN SDGs

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