Optimising Magnetic Sentinel Lymph Node Biopsy in an in vivo Porcine Model

Muneer Ahmed, Bauke Anninga, Joost J Pouw, Suzan Vreeman, Mirjam Peek, Mieke Van Hemelrijck, Bennie Ten Haken, Quentin Pankhurst, Michael Douek

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was a significant correlation between magnetometer counts and iron content of excised sentinel lymph nodes (SLNs) (r=0.82; P<0.001). Total number of SLNs increased with increasing volumes of magnetic tracer (P<0.001). Transcutaneous magnetometer counts increased with increasing time from injection of magnetic tracer (P<0.0001), plateauing within 60minutes. Increasing concentration resulted in higher iron content of SLNs (P=0.006), whilst a non-statistically significant trend was observed between volume injected and iron content of SLNs (P=0.07). Increasing magnetic tracer volume and injecting prior to surgery improves transcutaneous 'hotspot' identification but very high volumes, increase the number of nodes excised.

Original languageEnglish
Pages (from-to) 993–1002
Number of pages11
JournalNanomedicine : nanotechnology, biology, and medicine
Volume11
Issue number4
Early online date10 Feb 2015
DOIs
Publication statusPublished - May 2015

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