TY - JOUR
T1 - Optimization and assessment of a novel gastric electrode anchoring system designed to be implanted by minimally invasive surgery
AU - Debelle, Adrien
AU - de Rooster, Hilde
AU - Bianchini, Erika
AU - Lonys, Laurent
AU - Huberland, François
AU - Vanhoestenberghe, Anne
AU - Lambert, Pierre
AU - Acuña, Vicente
AU - Smets, Hugo
AU - Giannotta, Fabrizio
AU - Delchambre, Alain
AU - Sandersen, Charlotte
AU - Bolen, Geraldine
AU - Egyptien, Sophie
AU - Deleuze, Stefan
AU - Devière, Jacques
AU - Nonclercq, Antoine
N1 - Publisher Copyright:
© 2021
PY - 2021/6
Y1 - 2021/6
N2 - A novel electrode anchoring design and its implantation procedure, aiming for a minimally invasive solution for gastric electrical stimulation, are presented. The system comprises an anchor made of a flexible body embedding two needle-shaped electrodes. The electrodes can easily switch from a parallel position – to pierce the stomach – to a diverging position – enabling them to remain firmly anchored into the muscular layer of the stomach. Key device parameters governing anchoring stability were assessed on a traction test bench, and optimal values were derived. The device was then implanted in six dogs by open surgery to assess its anchoring durability in vivo. Computed tomography images showed that the electrodes remained well placed within the dogs’ gastric wall over the entire assessment period (more than one year). Finally, a prototype of a surgical tool for the minimally invasive device placement was manufactured, and the anchoring procedure was tested on a dog cadaver, providing the proof of concept of the minimally invasive implantation procedure. The use of our electrode anchoring system in long-term gastric electrical stimulation is promising in terms of implantation stability (the anchor withstands a force up to 0.81 N), durability (the anchor remains onto the stomach over one year) and minimal invasiveness of the procedure (the diameter of the percutaneous access is smaller than 12 mm). Moreover, the proposed design could have clinical applications in other hollow organs, such as the urinary bladder.
AB - A novel electrode anchoring design and its implantation procedure, aiming for a minimally invasive solution for gastric electrical stimulation, are presented. The system comprises an anchor made of a flexible body embedding two needle-shaped electrodes. The electrodes can easily switch from a parallel position – to pierce the stomach – to a diverging position – enabling them to remain firmly anchored into the muscular layer of the stomach. Key device parameters governing anchoring stability were assessed on a traction test bench, and optimal values were derived. The device was then implanted in six dogs by open surgery to assess its anchoring durability in vivo. Computed tomography images showed that the electrodes remained well placed within the dogs’ gastric wall over the entire assessment period (more than one year). Finally, a prototype of a surgical tool for the minimally invasive device placement was manufactured, and the anchoring procedure was tested on a dog cadaver, providing the proof of concept of the minimally invasive implantation procedure. The use of our electrode anchoring system in long-term gastric electrical stimulation is promising in terms of implantation stability (the anchor withstands a force up to 0.81 N), durability (the anchor remains onto the stomach over one year) and minimal invasiveness of the procedure (the diameter of the percutaneous access is smaller than 12 mm). Moreover, the proposed design could have clinical applications in other hollow organs, such as the urinary bladder.
KW - Electrode anchoring
KW - Percutaneous implantation
KW - Single incision surgery
KW - In-vivo validation
KW - Gastric electrical stimulation
UR - http://www.scopus.com/inward/record.url?scp=85107091256&partnerID=8YFLogxK
U2 - 10.1016/j.medengphy.2021.05.004
DO - 10.1016/j.medengphy.2021.05.004
M3 - Article
C2 - 34167717
SN - 1350-4533
VL - 92
SP - 93
EP - 101
JO - Medical Engineering and Physics
JF - Medical Engineering and Physics
ER -