Oral effects of low-dose methotrexate treatment

A Kalantzis, Z Marshman, D T Falconer, P R Morgan, E W Odell

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86 Citations (Scopus)


Methotrexate is used increasingly in low-dose regimes for a variety of conditions, particularly rheumatoid arthritis. While certain adverse effects of low-dose methotrexate have been described in detail, oral complications have received little attention. This article includes a summary of the uses and pharmacology of low-dose methotrexate and the mechanisms that lead to general and oral toxicity. The literature relevant to potential oral adverse effects is discussed and 7 illustrative cases are presented. The oral effects noted range from nonhealing ulcers to lymphoma-like lesions. Dental practitioners should be aware of the possible oral effects of low-dose methotrexate that have so far been largely unrecognized.
Original languageEnglish
Pages (from-to)52 - 62
Number of pages11
JournalOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics
Issue number1
Publication statusPublished - Jul 2005

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