Oral effects of low-dose methotrexate treatment

TY - JOUR

T1 - Oral effects of low-dose methotrexate treatment

AU - Kalantzis, A

AU - Marshman, Z

AU - Falconer, D T

AU - Morgan, P R

AU - Odell, E W

PY - 2005/7

Y1 - 2005/7

N2 - Methotrexate is used increasingly in low-dose regimes for a variety of conditions, particularly rheumatoid arthritis. While certain adverse effects of low-dose methotrexate have been described in detail, oral complications have received little attention. This article includes a summary of the uses and pharmacology of low-dose methotrexate and the mechanisms that lead to general and oral toxicity. The literature relevant to potential oral adverse effects is discussed and 7 illustrative cases are presented. The oral effects noted range from nonhealing ulcers to lymphoma-like lesions. Dental practitioners should be aware of the possible oral effects of low-dose methotrexate that have so far been largely unrecognized.

AB - Methotrexate is used increasingly in low-dose regimes for a variety of conditions, particularly rheumatoid arthritis. While certain adverse effects of low-dose methotrexate have been described in detail, oral complications have received little attention. This article includes a summary of the uses and pharmacology of low-dose methotrexate and the mechanisms that lead to general and oral toxicity. The literature relevant to potential oral adverse effects is discussed and 7 illustrative cases are presented. The oral effects noted range from nonhealing ulcers to lymphoma-like lesions. Dental practitioners should be aware of the possible oral effects of low-dose methotrexate that have so far been largely unrecognized.

U2 - 10.1016/j.tripleo.2004.08.020

DO - 10.1016/j.tripleo.2004.08.020

M3 - Article

VL - 100

SP - 52

EP - 62

JO - Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics

JF - Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics

IS - 1

ER -