Oral Mucosa: Physiological and Physicochemical Aspects

Gleb E. Yakubov; Hannah Gibbins; Gordon B. Proctor; Guy H. Carpenter

doi:10.1002/9781118794203.ch01

Oral Mucosa: Physiological and Physicochemical Aspects

Gleb E. Yakubov^*, Hannah Gibbins, Gordon B. Proctor, Guy H. Carpenter

^*Corresponding author for this work

Centre for Host Microbiome Interactions

University of Queensland

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

8 Citations (Scopus)

Abstract

Oral mucosa is a highly diverse, dynamic and responsive environment that despite high accessibility presents a number of challenges for oral drug delivery and food processing alike. This chapter focuses on the structure and physiological and physicochemical functions of mucosa on soft oral tissues, since soft surfaces are key targets for oral transmucosal drug carriers. There are six major classes of salivary proteins/glycoproteins: mucins (represented by MUC5B and MUC7 genetic types); acidic, basic and heavily glycosylated proline-rich proteins; salivary amylases; statherins; histatins; and cystatins. Salivary pellicle is critical factor in transport properties of topically delivered drugs and colloidal drug carriers. The chapter discusses the surface architecture, and mechanical, rheological and transport properties of salivary pellicle.

Original language	English
Title of host publication	Mucoadhesive Materials and Drug Delivery Systems
Publisher	WILEY-BLACKWELL
Pages	1-38
Number of pages	38
ISBN (Print)	9781118794203, 9781119941439
DOIs	https://doi.org/10.1002/9781118794203.ch01
Publication status	Published - 12 May 2014

Keywords

Drug delivery systems
Oral cavity tissues
Oral mucosa
Physicochemical properties
Physiological functions
Salivary glands
Salivary pellicle

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10.1002/9781118794203.ch01

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Oral Mucosa: Physiological and Physicochemical Aspects

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Keywords

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