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Oral Submucous Fibrosis: A review of the current management and possible directions for novel therapies

Research output: Contribution to journalArticle

Original languageEnglish
JournalOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics
Early online date19 Apr 2016
Publication statusE-pub ahead of print - 19 Apr 2016


King's Authors


This literature review addressed the tried out interventions for the management of oral submucous fibrosis. The literature supports the use of several medical interventions, including micronutrients, anti-oxidants, proteolytic enzymes, immune modulators (mainly steroids), and agents to promote blood flow. However, the numbers of reported randomized controlled trials are limited. Therefore, no recommendation can be made for any specific intervention. Until now, no single molecular pathway has been identified that is neither necessary nor sufficient for the development of fibrosis. This has been a bar for any molecular targeted therapies. Because areca nut (an ingredient of betel quid) plays a major aetiologic role in the causation of OSF cessation of areca nut use remains pivotal in the management of this disorder.

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