Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

Jin Li; Bing Liu; Tobias Banaschewski; Arun L.W. Bokde; Erin Burke Quinlan; Sylvane Desrivières; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Andreas Heinz; Bernd Ittermann; Jean Luc Martinot; Eric Artiges; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Sarah Hohmann; Juliane H. Fröhner; Michael N. Smolka; Henrik Walter; Robert Whelan; Gunter Schumann; Tianzi Jiang

doi:10.1017/S0033291720002962

Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

Jin Li
, Bing Liu
, Tobias Banaschewski
, Arun L.W. Bokde
, Erin Burke Quinlan
, Sylvane Desrivières
, Herta Flor
, Vincent Frouin
, Hugh Garavan
, Penny Gowland
, Andreas Heinz
, Bernd Ittermann
, Jean Luc Martinot
, Eric Artiges
, Frauke Nees
, Dimitri Papadopoulos Orfanos
, Tomáš Paus
, Luise Poustka
, Sarah Hohmann
, Juliane H. Fröhner

Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann^*, Tianzi Jiang

^*Corresponding author for this work

Chinese Academy of Sciences
Universitatsklinikum Mannheim
Department of Urology
Centre for Population Neuroscience and Precision Medicine
King's College London
Heidelberg University
Université Paris-Saclay
University of Vermont
University of Nottingham
Institute for Radiology, CCM
Physikalisch-Technische Bundesanstalt
Holland Bloorview Kids Rehabilitation Hospital
University Health Network, Toronto
University Medical Center Göttingen
TU Dresden
PONS Research Group
Humboldt-Universitat zu Berlin
Leibniz Institute for Neurobiology
Institute of Science and Technology for Brain-Inspired Intelligence
Fudan University
University of Queensland

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

BackgroundTobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood.MethodsGenomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-Analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use.ResultsA higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use.ConclusionsOur data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.

Original language	English
Journal	Psychological Medicine
DOIs	https://doi.org/10.1017/S0033291720002962
Publication status	Accepted/In press - 1 Jan 2020

Keywords

Cortical volume
orbitofrontal cortex
polygenic risk score
smoking
tobacco use

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10.1017/S0033291720002962

Cite this

Li, J., Liu, B., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., ... Jiang, T. (Accepted/In press). Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents. Psychological Medicine. https://doi.org/10.1017/S0033291720002962

@article{15dac002a4de4c5eb92bd15bd3f1e4e4,

title = "Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents",

abstract = "BackgroundTobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood.MethodsGenomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-Analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use.ResultsA higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use.ConclusionsOur data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure. ",

keywords = "Cortical volume, orbitofrontal cortex, polygenic risk score, smoking, tobacco use",

author = "Jin Li and Bing Liu and Tobias Banaschewski and Bokde, \{Arun L.W.\} and Quinlan, \{Erin Burke\} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Martinot, \{Jean Luc\} and Eric Artiges and Frauke Nees and \{Papadopoulos Orfanos\}, Dimitri and Tom{\'a}{\v s} Paus and Luise Poustka and Sarah Hohmann and Fr{\"o}hner, \{Juliane H.\} and Smolka, \{Michael N.\} and Henrik Walter and Robert Whelan and Gunter Schumann and Tianzi Jiang",

year = "2020",

month = jan,

day = "1",

doi = "10.1017/S0033291720002962",

language = "English",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

}

Li, J, Liu, B, Banaschewski, T, Bokde, ALW, Quinlan, EB , Desrivières, S, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, JL, Artiges, E, Nees, F, Papadopoulos Orfanos, D, Paus, T, Poustka, L, Hohmann, S, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G & Jiang, T 2020, 'Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents', Psychological Medicine. https://doi.org/10.1017/S0033291720002962

TY - JOUR

T1 - Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

AU - Li, Jin

AU - Liu, Bing

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean Luc

AU - Artiges, Eric

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Fröhner, Juliane H.

AU - Smolka, Michael N.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Jiang, Tianzi

PY - 2020/1/1

Y1 - 2020/1/1

N2 - BackgroundTobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood.MethodsGenomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-Analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use.ResultsA higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use.ConclusionsOur data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.

AB - BackgroundTobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood.MethodsGenomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-Analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use.ResultsA higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use.ConclusionsOur data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.

KW - Cortical volume

KW - orbitofrontal cortex

KW - polygenic risk score

KW - smoking

KW - tobacco use

UR - https://www.scopus.com/pages/publications/85091416300

U2 - 10.1017/S0033291720002962

DO - 10.1017/S0033291720002962

M3 - Article

AN - SCOPUS:85091416300

SN - 0033-2917

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

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Keywords

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