Orchestrating human neocortex development across the scales; from micro to macro

Marco Massimo; Katherine R. Long

doi:10.1016/j.semcdb.2021.09.007

Orchestrating human neocortex development across the scales; from micro to macro

Marco Massimo, Katherine R. Long^*

^*Corresponding author for this work

Developmental Neurobiology

King's College London

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.

Original language	English
Journal	Seminars in Cell and Developmental Biology
Early online date	25 Sept 2021
DOIs	https://doi.org/10.1016/j.semcdb.2021.09.007
Publication status	E-pub ahead of print - 25 Sept 2021

Keywords

Development
Human neocortex
Shape
Size

Access to Document

10.1016/j.semcdb.2021.09.007

Cite this

@article{af3d817de1ea4ccc8762dd3786764b76,

title = "Orchestrating human neocortex development across the scales; from micro to macro",

abstract = "How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.",

keywords = "Development, Human neocortex, Shape, Size",

author = "Marco Massimo and Long, {Katherine R.}",

note = "Funding Information: We would like to thank Nereo Kalebic for critical reading of the manuscript. KL is supported by a Career Development Award funded by the Medical Research Council [ MR/S025065/1 ]. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = sep,

day = "25",

doi = "10.1016/j.semcdb.2021.09.007",

language = "English",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Orchestrating human neocortex development across the scales; from micro to macro

AU - Massimo, Marco

AU - Long, Katherine R.

N1 - Funding Information: We would like to thank Nereo Kalebic for critical reading of the manuscript. KL is supported by a Career Development Award funded by the Medical Research Council [ MR/S025065/1 ]. Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9/25

Y1 - 2021/9/25

N2 - How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.

AB - How our brains have developed to perform the many complex functions that make us human has long remained a question of great interest. Over the last few decades, many scientists from a wide range of fields have tried to answer this question by aiming to uncover the mechanisms that regulate the development of the human neocortex. They have approached this on different scales, focusing microscopically on individual cells all the way up to macroscopically imaging entire brains within living patients. In this review we will summarise these key findings and how they fit together.

KW - Development

KW - Human neocortex

KW - Shape

KW - Size

UR - http://www.scopus.com/inward/record.url?scp=85115739567&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2021.09.007

DO - 10.1016/j.semcdb.2021.09.007

M3 - Article

AN - SCOPUS:85115739567

SN - 1084-9521

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Orchestrating human neocortex development across the scales; from micro to macro

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this