King's College London

Funding Information: K.D.-C.'s research was supported by a Marie Curie Initial Training Network: MUZIC (no. 238423); Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221; Federal Ministry of Economy, Family, and Youth through the initiative ?Laura Bassi Centres of Expertise,? funding the Centre of Optimized Structural Studies, no. 253275; the Wellcome Trust Collaborative Award (201543/Z/16); COST action BM1405-Non-globular proteins from sequence to structure, function and application in molecular physiopathology (NGP-NET); WWTF (Vienna Science and Technology Fund) Chemical Biology project LS17-008; Christian Doppler Laboratory for High-Content Structural Biology and Biotechnology; and the Austrian-Slovak Interreg Project B301 StruBioMol, University of Vienna Research Platform Comammox and by the University of Vienna. The work was supported by the Austrian Science Fund FWF grant P30550 to B.Z. M.G. and A.G. were supported by the Wellcome Trust Collaborative Award (201543/Z/16). M.G. holds the British Heart Foundation Chair of Molecular Cardiology. This work was supported by a grant from the Polish National Science Centre to W.K. (MAESTRO, 2015/18/A/ST4/00270). Research in B.W.'s laboratory was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) research FOR 2743, Project ID 403222702/SFB 1381, and Germany's Excellence Strategy (CIBSS-EXC-2189-Project ID 390939984). D.I.S. and C.M.J. acknowledge the support of the European Union's Horizon 2020 research and innovation programme ?iNEXT Discovery? grant agreement no. 871037. Publisher Copyright: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.