Organic Solvent-Free, One-Step Engineering of Graphene-Based Magnetic-Responsive Hybrids Using Design of Experiment-Driven Mechanochemistry

Kuo-Ching Mei, Yukuang Guo, Jie Bai, Pedro M. Costa, Houmam Kafa, Andrea Protti, Robert C. Hider, Khuloud T. Al-Jamal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)
148 Downloads (Pure)

Abstract

In this study, we propose an organic solvent-free, one-step mechanochemistry approach to engineer water-dispersible graphene oxide/superparamagnetic iron oxide (GO/SPIOs) hybrids, for biomedical applications. Although mechanochemistry has been proposed in the graphene field for applications such as drug loading, exfoliation or polymer-composite formation, this is the first study to report mechanochemistry for preparation of GO/SPIOs hybrids. The statistical design of experiment (DoE) was employed to control the process parameters. DoE has been used to control formulation processes of other types of nanomaterials. The implementation of DoE for controlling the formulation processes of graphene-based nanomaterials is, however, novel. DoE approach could be of advantage as one can tailor GO-based hybrids of predicted yields and compositions. Hybrids were characterized by TEM, AFM FT-IR, Raman spectroscopy, and TGA. The dose-response magnetic resonance (MR) properties were confirmed by MR imaging of phantoms. The biocompatibility of the hybrids with A549 and J774 cell lines was confirmed by the modified LDH assay.

Original languageEnglish
Pages (from-to)14176-14181
Number of pages6
JournalACS Applied Materials and Interfaces
Volume7
Issue number26
Early online date23 Jun 2015
DOIs
Publication statusPublished - 8 Jul 2015

Keywords

  • DoE
  • drug delivery
  • formulation
  • graphene
  • mechanochemistry
  • nanomedicine
  • SPIO
  • toxicity

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