Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: A retrospective study by the EBMT LWP

A. Bazarbachi*, K. Cwynarski, A. Boumendil, H. Finel, P. Fields, K. Raj, A. Nagler, M. Mohty, A. Sureda, P. Dreger, O. Hermine

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients received auto-SCT and rapidly died from ATL. Out of 17 allo-SCT (4 myeloablative, 13 reduced intensity), 6 are still alive (4 were in CR1 at SCT). Eleven patients died within 2 years, eight from relapse/progression and three from transplant toxicity. Six of seven informative patients who lived >12 months had chronic GVHD. Overall these results indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients.

Original languageEnglish
Pages (from-to)1266-1268
Number of pages3
JournalBone Marrow Transplantation
Volume49
Issue number10
DOIs
Publication statusPublished - 1 Jan 2014

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