OUTCOMES OF DEPRESSION UP TO 15 YEARS AFTER STROKE: A POPULATION-BASED STUDY

Lu Liu*, Iain Marshall, Ajay Bhalla, Ruonan Pei, Charles Wolfe, Matt O'Connell, Yanzhong Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Background and aims: Data on the long-term outcomes of post-stroke depression (PSD) are limited. We aim to estimate various outcomes of PSD up to 15-years after stroke and assess the differences by age.

Methods: Data were from the South London Stroke Register (1997-2022). Depression was assessed using the Hospital Anxiety and Depression Scale at 3-months post-stroke. Outcomes included mortality, recurrent stroke and yearly follow-up functional outcomes (physical ability, activity of daily living, cognitive function and quality of life). Cox proportional hazards models were used to estimate the association between depression and mortality and stroke recurrence. The associations with functional outcomes over 15-years post-troke were estimated using Generalized estimating equation (binary outcomes) and linear regression models (continuous outcomes), adjusting for age, sex, ethnicity, stroke severity, anti-depression medications and comorbidities.

Results: 2574 stroke survivors were assessed at 3-months and 913 (35.5%) had depression. Survivors with depression had higher risk of mortality (aHR 1.16, 95% CI 1.05–1.27), but similar risk of stroke recurrence (0.93 [0.70-1.23]) compared to those without depression to 15-years post-stroke. Patients with depression also had poorer physical abilities (aRR 1.79, [1.48-2.17]), higher risks of inactive activity of daily living (2.57, [2.06-3.18]) and cognitive impairment (1.33,[1.05-1.69]) and poorer physical (β=−2.75, -3.50 to-2.00) and mental quality of life (β=−6.29,-7.22 to-5.35). These associations were more pronounced in patients< 65 years.

Conclusions: PSD is associated with higher mortality, poorer functional outcomes and reduced quality of life up to 15-years after stroke and this association was more evident in younger patients. PSD doesn’t affect stroke recurrence.

Disclosures of Interest: No

Original languageEnglish
Article number1927
Pages (from-to)334-335
JournalEuropean Stroke Journal
Volume9
Issue number1_suppl
DOIs
Publication statusPublished - 15 May 2024

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