TY - JOUR
T1 - Outcomes of salvage surgery for the oropharynx and larynx
T2 - a contemporary experience in a UK Cancer Centre
AU - Hay, Ashley
AU - Simo, Ricard
AU - Hall, Gillian
AU - Thavaraj, Selvam
AU - Oakley, Richard
AU - Fry, Alastair
AU - Cascarini, Luke
AU - Lei, Mary
AU - Guerro-Urbano, Teresa
AU - Jeannon, Jean-Pierre
PY - 2019/4/1
Y1 - 2019/4/1
N2 - INTRODUCTION: The purpose of this study was to review our recent experience of salvage surgery, comparing larynx and oropharynx recurrence patterns.METHODS: A single centre, retrospective review of salvage surgery for recurrent head and neck cancer including patients between 2008 and 2016.RESULTS: 61 patients were identified, 36 underwent salvage laryngectomy and 25 received oropharyngeal resections. The median overall survival of oropharyngeal recurrent tumors was 26 months (95% CI 15-118 months) and for laryngeal tumors was 23 months (95% CI 11-38 months), p = 0.1008. There was a significant overall survival benefit in patients with negative resection margin. The median survival in the negative margin group was 38 months (95% CI 25-108 months) compared to the positive margin group, 9 months (95% CI 5-15 months), p < 0.0001.CONCLUSION: Survival results following surgical salvage in the larynx and oropharynx appear to be similarly poor. Those patients with clear margins appear to have a significantly better prognosis.
AB - INTRODUCTION: The purpose of this study was to review our recent experience of salvage surgery, comparing larynx and oropharynx recurrence patterns.METHODS: A single centre, retrospective review of salvage surgery for recurrent head and neck cancer including patients between 2008 and 2016.RESULTS: 61 patients were identified, 36 underwent salvage laryngectomy and 25 received oropharyngeal resections. The median overall survival of oropharyngeal recurrent tumors was 26 months (95% CI 15-118 months) and for laryngeal tumors was 23 months (95% CI 11-38 months), p = 0.1008. There was a significant overall survival benefit in patients with negative resection margin. The median survival in the negative margin group was 38 months (95% CI 25-108 months) compared to the positive margin group, 9 months (95% CI 5-15 months), p < 0.0001.CONCLUSION: Survival results following surgical salvage in the larynx and oropharynx appear to be similarly poor. Those patients with clear margins appear to have a significantly better prognosis.
KW - Larynx cancer
KW - Oropharynx cancer
KW - Recurrent head and neck cancer
KW - Salvage surgery
UR - http://www.scopus.com/inward/record.url?scp=85060437924&partnerID=8YFLogxK
U2 - 10.1007/s00405-019-05295-x
DO - 10.1007/s00405-019-05295-x
M3 - Review article
C2 - 30666441
SN - 1434-4726
VL - 276
SP - 1153
EP - 1159
JO - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
IS - 4
ER -
