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Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

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Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. / Hernandez-Diaz, Ivan; Pan, Jiaqi; Ricciardi, Carlo Alberto; Bai, Xiaoyan; Ke, Jianting; White, Kathryn E; Flaquer, Maria; Fouli, Georgia E; Argunhan, Fulye; Hayward, Anthea E; Hou, Fan Fan; Mann, Giovanni E; Miao, Robert Q; Long, David A; Gnudi, Luigi.

In: Diabetes, Vol. 68, No. 9, 01.09.2019, p. 1841-1852.

Research output: Contribution to journalArticle

Harvard

Hernandez-Diaz, I, Pan, J, Ricciardi, CA, Bai, X, Ke, J, White, KE, Flaquer, M, Fouli, GE, Argunhan, F, Hayward, AE, Hou, FF, Mann, GE, Miao, RQ, Long, DA & Gnudi, L 2019, 'Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature', Diabetes, vol. 68, no. 9, pp. 1841-1852. https://doi.org/10.2337/db19-0157

APA

Hernandez-Diaz, I., Pan, J., Ricciardi, C. A., Bai, X., Ke, J., White, K. E., ... Gnudi, L. (2019). Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes, 68(9), 1841-1852. https://doi.org/10.2337/db19-0157

Vancouver

Hernandez-Diaz I, Pan J, Ricciardi CA, Bai X, Ke J, White KE et al. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes. 2019 Sep 1;68(9):1841-1852. https://doi.org/10.2337/db19-0157

Author

Hernandez-Diaz, Ivan ; Pan, Jiaqi ; Ricciardi, Carlo Alberto ; Bai, Xiaoyan ; Ke, Jianting ; White, Kathryn E ; Flaquer, Maria ; Fouli, Georgia E ; Argunhan, Fulye ; Hayward, Anthea E ; Hou, Fan Fan ; Mann, Giovanni E ; Miao, Robert Q ; Long, David A ; Gnudi, Luigi. / Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. In: Diabetes. 2019 ; Vol. 68, No. 9. pp. 1841-1852.

Bibtex Download

@article{fc15f6eec3d242b19c468b773c54264f,
title = "Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature",
abstract = "Damage to the vasculature is the primary mechanism driving chronic diabetic microvascular complications such as diabetic nephropathy which manifests as albuminuria. Therefore, treatments that protect the diabetic vasculature have significant therapeutic potential. Soluble Neurite outgrowth inhibitor-B (sNogo-B) is a circulating N-terminus isoform of full-length Nogo-B which plays a key role in vascular remodelling following injury. However, there is currently no information on the role of sNogo-B in the context of diabetic nephropathy. We demonstrate that overexpression of sNogo-B in the circulation ameliorates diabetic kidney disease by reducing albuminuria, hyperfiltration, abnormal angiogenesis and protecting glomerular capillary structure. Systemic sNogo-B overexpression in diabetic mice also associates with dampening VEGF-A signalling and reducing eNOS, AKT and GSK3β phosphorylation. Furthermore, sNogo-B prevented the impairment of tube formation which occurred when human endothelial cells were exposed to sera from patients with diabetic kidney disease. Collectively, these studies provide the first evidence that sNogo-B protects the vasculature in diabetes and may represent a novel therapeutic target for diabetic vascular complications.",
author = "Ivan Hernandez-Diaz and Jiaqi Pan and Ricciardi, {Carlo Alberto} and Xiaoyan Bai and Jianting Ke and White, {Kathryn E} and Maria Flaquer and Fouli, {Georgia E} and Fulye Argunhan and Hayward, {Anthea E} and Hou, {Fan Fan} and Mann, {Giovanni E} and Miao, {Robert Q} and Long, {David A} and Luigi Gnudi",
note = "{\circledC} 2019 by the American Diabetes Association.",
year = "2019",
month = "9",
day = "1",
doi = "10.2337/db19-0157",
language = "English",
volume = "68",
pages = "1841--1852",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

AU - Hernandez-Diaz, Ivan

AU - Pan, Jiaqi

AU - Ricciardi, Carlo Alberto

AU - Bai, Xiaoyan

AU - Ke, Jianting

AU - White, Kathryn E

AU - Flaquer, Maria

AU - Fouli, Georgia E

AU - Argunhan, Fulye

AU - Hayward, Anthea E

AU - Hou, Fan Fan

AU - Mann, Giovanni E

AU - Miao, Robert Q

AU - Long, David A

AU - Gnudi, Luigi

N1 - © 2019 by the American Diabetes Association.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Damage to the vasculature is the primary mechanism driving chronic diabetic microvascular complications such as diabetic nephropathy which manifests as albuminuria. Therefore, treatments that protect the diabetic vasculature have significant therapeutic potential. Soluble Neurite outgrowth inhibitor-B (sNogo-B) is a circulating N-terminus isoform of full-length Nogo-B which plays a key role in vascular remodelling following injury. However, there is currently no information on the role of sNogo-B in the context of diabetic nephropathy. We demonstrate that overexpression of sNogo-B in the circulation ameliorates diabetic kidney disease by reducing albuminuria, hyperfiltration, abnormal angiogenesis and protecting glomerular capillary structure. Systemic sNogo-B overexpression in diabetic mice also associates with dampening VEGF-A signalling and reducing eNOS, AKT and GSK3β phosphorylation. Furthermore, sNogo-B prevented the impairment of tube formation which occurred when human endothelial cells were exposed to sera from patients with diabetic kidney disease. Collectively, these studies provide the first evidence that sNogo-B protects the vasculature in diabetes and may represent a novel therapeutic target for diabetic vascular complications.

AB - Damage to the vasculature is the primary mechanism driving chronic diabetic microvascular complications such as diabetic nephropathy which manifests as albuminuria. Therefore, treatments that protect the diabetic vasculature have significant therapeutic potential. Soluble Neurite outgrowth inhibitor-B (sNogo-B) is a circulating N-terminus isoform of full-length Nogo-B which plays a key role in vascular remodelling following injury. However, there is currently no information on the role of sNogo-B in the context of diabetic nephropathy. We demonstrate that overexpression of sNogo-B in the circulation ameliorates diabetic kidney disease by reducing albuminuria, hyperfiltration, abnormal angiogenesis and protecting glomerular capillary structure. Systemic sNogo-B overexpression in diabetic mice also associates with dampening VEGF-A signalling and reducing eNOS, AKT and GSK3β phosphorylation. Furthermore, sNogo-B prevented the impairment of tube formation which occurred when human endothelial cells were exposed to sera from patients with diabetic kidney disease. Collectively, these studies provide the first evidence that sNogo-B protects the vasculature in diabetes and may represent a novel therapeutic target for diabetic vascular complications.

UR - http://www.scopus.com/inward/record.url?scp=85071517347&partnerID=8YFLogxK

U2 - 10.2337/db19-0157

DO - 10.2337/db19-0157

M3 - Article

C2 - 31217174

VL - 68

SP - 1841

EP - 1852

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 9

ER -

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