Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

ISAAC Phase Two Steering Group

doi:10.1371/journal.pone.0113996

Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

ISAAC Phase Two Steering Group

Dermatology

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

Original language	English
Article number	e113996
Journal	PLoS ONE
Volume	9
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0113996
Publication status	Published - 4 Dec 2014

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@article{340fb79f8c9e4659a419c6197e2a4589,

title = "Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two",

abstract = "Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.",

author = "{ISAAC Phase Two Steering Group} and Gudrun Weinmayr and Francesco Forastiere and Gisela B{\"u}chele and Andrea Jaensch and Strachan, {David P.} and Gabriele Nagel and Weiland, {S. K.} and C. Dentler and P. Rzehak and A. Priftanji and A. Shkurti and J. Simenati and E. Grabocka and K. Shyti and S. Agolli and A. Gurakuqi and Stein, {R. T.} and {De Pereira}, {M. Urrutia} and Jones, {M. H.} and Pitrez, {P. M.} and Cooper, {P. J.} and M. Chico and Chen, {Y. Z.} and Zhong, {N. S.} and Lai, {C. K.W.} and Wong, {G. W.K.} and Riikj{\"a}rv, {M. A.} and T. Annus and I. Annesi-Maesano and M. Gotua and M. Rukhadze and T. Abramidze and I. Kvachadze and L. Karsanidze and M. Kiladze and N. Dolidze and W. Leupold and U. Keil and {Von Mutius}, E. and P. Arthur and E. Addo-Yobo and C. Gratziou and K. Priftis and A. Papadopoulou and C. Katsardis and J. Tsanakas and E. Hatziagorou and F. Kirvassilis and M. Clausen and C. Flohr",

note = "Publisher Copyright: {\textcopyright} 2014 Weinmayr et al.",

year = "2014",

month = dec,

day = "4",

doi = "10.1371/journal.pone.0113996",

language = "English",

volume = "9",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

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TY - JOUR

T1 - Overweight/obesity and respiratory and allergic disease in children

T2 - International study of asthma and allergies in childhood (ISAAC) phase two

AU - ISAAC Phase Two Steering Group

AU - Weinmayr, Gudrun

AU - Forastiere, Francesco

AU - Büchele, Gisela

AU - Jaensch, Andrea

AU - Strachan, David P.

AU - Nagel, Gabriele

AU - Weiland, S. K.

AU - Dentler, C.

AU - Rzehak, P.

AU - Priftanji, A.

AU - Shkurti, A.

AU - Simenati, J.

AU - Grabocka, E.

AU - Shyti, K.

AU - Agolli, S.

AU - Gurakuqi, A.

AU - Stein, R. T.

AU - De Pereira, M. Urrutia

AU - Jones, M. H.

AU - Pitrez, P. M.

AU - Cooper, P. J.

AU - Chico, M.

AU - Chen, Y. Z.

AU - Zhong, N. S.

AU - Lai, C. K.W.

AU - Wong, G. W.K.

AU - Riikjärv, M. A.

AU - Annus, T.

AU - Annesi-Maesano, I.

AU - Gotua, M.

AU - Rukhadze, M.

AU - Abramidze, T.

AU - Kvachadze, I.

AU - Karsanidze, L.

AU - Kiladze, M.

AU - Dolidze, N.

AU - Leupold, W.

AU - Keil, U.

AU - Von Mutius, E.

AU - Arthur, P.

AU - Addo-Yobo, E.

AU - Gratziou, C.

AU - Priftis, K.

AU - Papadopoulou, A.

AU - Katsardis, C.

AU - Tsanakas, J.

AU - Hatziagorou, E.

AU - Kirvassilis, F.

AU - Clausen, M.

AU - Flohr, C.

PY - 2014/12/4

Y1 - 2014/12/4

N2 - Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

AB - Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

UR - http://www.scopus.com/inward/record.url?scp=84915746668&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0113996

DO - 10.1371/journal.pone.0113996

M3 - Article

C2 - 25474308

AN - SCOPUS:84915746668

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 12

M1 - e113996

ER -

Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

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