Ownership Illusions in Patients with Body Delusions: Different Neural Profiles of Visual Capture and Disownership

TY - JOUR

T1 - Ownership Illusions in Patients with Body Delusions

T2 - Different Neural Profiles of Visual Capture and Disownership

AU - Martinaud, Olivier

AU - Besharati, Sahba

AU - Jenkinson, Paul M.

AU - Fotopoulou, Aikaterini

PY - 2016/10/19

Y1 - 2016/10/19

N2 - AbstractThe various neurocognitive processes contributing to the sense of body ownership have been investigated extensively in healthy participants, but studies in neurological patients can shed unique light into such phenomena. Here, we aimed to investigate whether visual capture by a fake hand (without any synchronous or asynchronous tactile stimulation) affects body ownership in a group of hemiplegic patients with or without disturbances in the sense of somatic ownership (DSO) following damage to the right hemisphere. We recruited 31 consecutive patients, including seven patients with DSO. The majority of our patients (64.5% overall and up to 86% of the patients with DSO) experienced strong feelings of ownership over a rubber hand within 15 seconds following mere visual exposure, which correlated with the degree of proprioceptive deficits across groups and in the DSO group. Using voxel-based lesion-symptom mapping analysis, we were able to identify lesions associated with this pathological visual capture effect in a selective fronto-parietal network, including significant voxels (p < 0.05) in the frontal operculum and the inferior frontal gyrus. By contrast, lesions associated with DSO involved more posterior lesions, including the right temporoparietal junction and a large area of the supramarginal gyrus, and to a lesser degree the middle frontal gyrus. Thus, this study suggests that our sense of ownership includes dissociable mechanisms of multisensory integration.

AB - AbstractThe various neurocognitive processes contributing to the sense of body ownership have been investigated extensively in healthy participants, but studies in neurological patients can shed unique light into such phenomena. Here, we aimed to investigate whether visual capture by a fake hand (without any synchronous or asynchronous tactile stimulation) affects body ownership in a group of hemiplegic patients with or without disturbances in the sense of somatic ownership (DSO) following damage to the right hemisphere. We recruited 31 consecutive patients, including seven patients with DSO. The majority of our patients (64.5% overall and up to 86% of the patients with DSO) experienced strong feelings of ownership over a rubber hand within 15 seconds following mere visual exposure, which correlated with the degree of proprioceptive deficits across groups and in the DSO group. Using voxel-based lesion-symptom mapping analysis, we were able to identify lesions associated with this pathological visual capture effect in a selective fronto-parietal network, including significant voxels (p < 0.05) in the frontal operculum and the inferior frontal gyrus. By contrast, lesions associated with DSO involved more posterior lesions, including the right temporoparietal junction and a large area of the supramarginal gyrus, and to a lesser degree the middle frontal gyrus. Thus, this study suggests that our sense of ownership includes dissociable mechanisms of multisensory integration.

KW - anosognosia for hemiplegia

KW - asomatognosia

KW - motor awareness

KW - sense of body ownership

KW - rubber hand illusion

KW - visual capture

KW - interoception

KW - proprioception

KW - insula

KW - premotor cortex

U2 - 10.1016/j.cortex.2016.09.025

DO - 10.1016/j.cortex.2016.09.025

M3 - Article

SN - 0010-9452

JO - Cortex

JF - Cortex

ER -