Pacing Interventions in non-responders to cardiac resynchronization therapy

Nadeev Wijesuriya; Vishal Mehta; Mark Elliott; Felicity De Vere; Marina Strocchi; Jonathan Behar; Steven Niederer; Christopher Aldo Rinaldi

Pacing Interventions in non-responders to cardiac resynchronization therapy

Nadeev Wijesuriya, Vishal Mehta, Mark Elliott, Felicity De Vere, Marina Strocchi, Jonathan Behar, Steven Niederer, Christopher Aldo Rinaldi

Research output: Contribution to journal › Review article › peer-review

Abstract

Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

Original language	English
Journal	Frontiers in Physiology
Publication status	Accepted/In press - 20 Jan 2023

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title = "Pacing Interventions in non-responders to cardiac resynchronization therapy",

abstract = "Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing. ",

author = "Nadeev Wijesuriya and Vishal Mehta and Mark Elliott and {De Vere}, Felicity and Marina Strocchi and Jonathan Behar and Steven Niederer and Rinaldi, {Christopher Aldo}",

year = "2023",

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day = "20",

language = "English",

journal = "Frontiers in Physiology",

issn = "1664-042X",

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TY - JOUR

T1 - Pacing Interventions in non-responders to cardiac resynchronization therapy

AU - Wijesuriya, Nadeev

AU - Mehta, Vishal

AU - Elliott, Mark

AU - De Vere, Felicity

AU - Strocchi, Marina

AU - Behar, Jonathan

AU - Niederer, Steven

AU - Rinaldi, Christopher Aldo

PY - 2023/1/20

Y1 - 2023/1/20

N2 - Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

AB - Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

M3 - Review article

SN - 1664-042X

JO - Frontiers in Physiology

JF - Frontiers in Physiology

ER -

Pacing Interventions in non-responders to cardiac resynchronization therapy

Abstract

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