Pacing interventions in non-responders to cardiac resynchronization therapy

Nadeev Wijesuriya; Mark K. Elliott; Vishal Mehta; Felicity De Vere; Marina Strocchi; Jonathan M. Behar; Steven A. Niederer; Christopher A. Rinaldi

doi:10.3389/fphys.2023.1054095

Pacing interventions in non-responders to cardiac resynchronization therapy

Nadeev Wijesuriya^*, Mark K. Elliott, Vishal Mehta, Felicity De Vere, Marina Strocchi, Jonathan M. Behar, Steven A. Niederer, Christopher A. Rinaldi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

Original language	English
Article number	1054095
Journal	Frontiers in Physiology
Volume	14
DOIs	https://doi.org/10.3389/fphys.2023.1054095
Publication status	Published - 26 Jan 2023

Keywords

conduction system pacing
CRT
CRT non-response
endocardial pacing
leadless cardiac resynchronization therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fphys.2023.1054095

Cite this

@article{c34b8244f55d49d1a6f420690c79f505,

title = "Pacing interventions in non-responders to cardiac resynchronization therapy",

abstract = "Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.",

keywords = "conduction system pacing, CRT, CRT non-response, endocardial pacing, leadless cardiac resynchronization therapy",

author = "Nadeev Wijesuriya and Elliott, {Mark K.} and Vishal Mehta and {De Vere}, Felicity and Marina Strocchi and Behar, {Jonathan M.} and Niederer, {Steven A.} and Rinaldi, {Christopher A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Wijesuriya, Elliott, Mehta, De Vere, Strocchi, Behar, Niederer and Rinaldi.",

year = "2023",

month = jan,

day = "26",

doi = "10.3389/fphys.2023.1054095",

language = "English",

volume = "14",

journal = "Frontiers in Physiology",

issn = "1664-042X",

publisher = "Frontiers",

}

TY - JOUR

T1 - Pacing interventions in non-responders to cardiac resynchronization therapy

AU - Wijesuriya, Nadeev

AU - Elliott, Mark K.

AU - Mehta, Vishal

AU - De Vere, Felicity

AU - Strocchi, Marina

AU - Behar, Jonathan M.

AU - Niederer, Steven A.

AU - Rinaldi, Christopher A.

PY - 2023/1/26

Y1 - 2023/1/26

N2 - Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

AB - Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is “conventional” biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.

KW - conduction system pacing

KW - CRT

KW - CRT non-response

KW - endocardial pacing

KW - leadless cardiac resynchronization therapy

UR - http://www.scopus.com/inward/record.url?scp=85147658512&partnerID=8YFLogxK

U2 - 10.3389/fphys.2023.1054095

DO - 10.3389/fphys.2023.1054095

M3 - Review article

AN - SCOPUS:85147658512

SN - 1664-042X

VL - 14

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 1054095

ER -

Pacing interventions in non-responders to cardiac resynchronization therapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this