Pain in people living with HIV and its association with healthcare resource use, well being and functional status

Caroline A. Sabin; Richard Harding; Emmanouil Bagkeris; Kennedy Nkhoma; Frank A. Post; Memory Sachikonye; Marta Boffito; Jane Anderson; Patrick W.G. Mallon; Ian Williams; Jaime Vera; Margaret Johnson; Daphne Babalis; Alan Winston

doi:10.1097/QAD.0000000000002021

Pain in people living with HIV and its association with healthcare resource use, well being and functional status

Caroline A. Sabin, Richard Harding, Emmanouil Bagkeris, Kennedy Nkhoma, Frank A. Post, Memory Sachikonye, Marta Boffito, Jane Anderson, Patrick W.G. Mallon, Ian Williams, Jaime Vera, Margaret Johnson, Daphne Babalis, Alan Winston

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Abstract

OBJECTIVE: We describe the prevalence of pain and its associations with healthcare resource utilization and quality-of-life. DESIGN: The POPPY Study recruited three cohorts: older people living with HIV (PLWH; ≥50 years, n = 699), younger demographically/lifestyle similar PLWH (less than 50 years, n = 374) and older demographically/lifestyle similar HIV-negative (≥50 years, n = 304) people from April 2013 to February 2016. METHODS: Current pain and pain-related healthcare use was collected via a self-reported questionnaire. Logistic regression assessed between-group differences in the prevalence of pain in the past month and current pain after controlling for potential confounders. Associations between current pain and healthcare resource use, reported joint problems, depressive symptoms, quality-of-life and functional status were assessed in PLWH using Mann-Whitney U and chi-squared tests. RESULTS: Pain in the past month was reported by 473 out of 676 (70.0%) older PLWH, 224 out of 357 (62.7%) younger PLWH and 188 out of 295 (63.7%) older HIV-negative controls (P = 0.03), with current pain reported in 330 (48.8%), 134 (37.5%) and 116 (39.3%), respectively (P = 0.0007). Older PLWH were more likely to experience current pain, even after adjustment for confounders. Of those with pain in the past month, 56 out of 412 (13.6%) had missed days of work or study due to pain, and 520 (59%) had seen a doctor about their pain. PLWH experiencing current pain had more depressive symptoms, poorer quality-of-life on all domains and greater functional impairment, regardless of age group. CONCLUSION: Even in the effective antiretroviral therapy era, pain remains common in PLWH and has a major impact on quality-of-life and associated healthcare and societal costs. Interventions are required to assist clinicians and PLWH to proactively manage pain.

Original language	English
Pages (from-to)	2697-2706
Number of pages	10
Journal	AIDS (London, England)
Volume	32
Issue number	18
Early online date	28 Nov 2018
DOIs	https://doi.org/10.1097/QAD.0000000000002021
Publication status	Published - Nov 2018

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Pain in people living with_SABINE_Publishedonline28November2018_GREEN AAMAccepted author manuscript, 421 KB

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Sabin, C. A., Harding, R., Bagkeris, E., Nkhoma, K., Post, F. A., Sachikonye, M., Boffito, M., Anderson, J., Mallon, P. W. G., Williams, I., Vera, J., Johnson, M., Babalis, D., & Winston, A. (2018). Pain in people living with HIV and its association with healthcare resource use, well being and functional status. AIDS (London, England), 32(18), 2697-2706. https://doi.org/10.1097/QAD.0000000000002021

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title = "Pain in people living with HIV and its association with healthcare resource use, well being and functional status",

abstract = "OBJECTIVE: We describe the prevalence of pain and its associations with healthcare resource utilization and quality-of-life. DESIGN: The POPPY Study recruited three cohorts: older people living with HIV (PLWH; ≥50 years, n = 699), younger demographically/lifestyle similar PLWH (less than 50 years, n = 374) and older demographically/lifestyle similar HIV-negative (≥50 years, n = 304) people from April 2013 to February 2016. METHODS: Current pain and pain-related healthcare use was collected via a self-reported questionnaire. Logistic regression assessed between-group differences in the prevalence of pain in the past month and current pain after controlling for potential confounders. Associations between current pain and healthcare resource use, reported joint problems, depressive symptoms, quality-of-life and functional status were assessed in PLWH using Mann-Whitney U and chi-squared tests. RESULTS: Pain in the past month was reported by 473 out of 676 (70.0%) older PLWH, 224 out of 357 (62.7%) younger PLWH and 188 out of 295 (63.7%) older HIV-negative controls (P = 0.03), with current pain reported in 330 (48.8%), 134 (37.5%) and 116 (39.3%), respectively (P = 0.0007). Older PLWH were more likely to experience current pain, even after adjustment for confounders. Of those with pain in the past month, 56 out of 412 (13.6%) had missed days of work or study due to pain, and 520 (59%) had seen a doctor about their pain. PLWH experiencing current pain had more depressive symptoms, poorer quality-of-life on all domains and greater functional impairment, regardless of age group. CONCLUSION: Even in the effective antiretroviral therapy era, pain remains common in PLWH and has a major impact on quality-of-life and associated healthcare and societal costs. Interventions are required to assist clinicians and PLWH to proactively manage pain.",

author = "Sabin, {Caroline A.} and Richard Harding and Emmanouil Bagkeris and Kennedy Nkhoma and Post, {Frank A.} and Memory Sachikonye and Marta Boffito and Jane Anderson and Mallon, {Patrick W.G.} and Ian Williams and Jaime Vera and Margaret Johnson and Daphne Babalis and Alan Winston",

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Sabin, CA, Harding, R, Bagkeris, E, Nkhoma, K, Post, FA, Sachikonye, M, Boffito, M, Anderson, J, Mallon, PWG, Williams, I, Vera, J, Johnson, M, Babalis, D & Winston, A 2018, 'Pain in people living with HIV and its association with healthcare resource use, well being and functional status', AIDS (London, England), vol. 32, no. 18, pp. 2697-2706. https://doi.org/10.1097/QAD.0000000000002021

TY - JOUR

T1 - Pain in people living with HIV and its association with healthcare resource use, well being and functional status

AU - Sabin, Caroline A.

AU - Harding, Richard

AU - Bagkeris, Emmanouil

AU - Nkhoma, Kennedy

AU - Post, Frank A.

AU - Sachikonye, Memory

AU - Boffito, Marta

AU - Anderson, Jane

AU - Mallon, Patrick W.G.

AU - Williams, Ian

AU - Vera, Jaime

AU - Johnson, Margaret

AU - Babalis, Daphne

AU - Winston, Alan

PY - 2018/11

Y1 - 2018/11

N2 - OBJECTIVE: We describe the prevalence of pain and its associations with healthcare resource utilization and quality-of-life. DESIGN: The POPPY Study recruited three cohorts: older people living with HIV (PLWH; ≥50 years, n = 699), younger demographically/lifestyle similar PLWH (less than 50 years, n = 374) and older demographically/lifestyle similar HIV-negative (≥50 years, n = 304) people from April 2013 to February 2016. METHODS: Current pain and pain-related healthcare use was collected via a self-reported questionnaire. Logistic regression assessed between-group differences in the prevalence of pain in the past month and current pain after controlling for potential confounders. Associations between current pain and healthcare resource use, reported joint problems, depressive symptoms, quality-of-life and functional status were assessed in PLWH using Mann-Whitney U and chi-squared tests. RESULTS: Pain in the past month was reported by 473 out of 676 (70.0%) older PLWH, 224 out of 357 (62.7%) younger PLWH and 188 out of 295 (63.7%) older HIV-negative controls (P = 0.03), with current pain reported in 330 (48.8%), 134 (37.5%) and 116 (39.3%), respectively (P = 0.0007). Older PLWH were more likely to experience current pain, even after adjustment for confounders. Of those with pain in the past month, 56 out of 412 (13.6%) had missed days of work or study due to pain, and 520 (59%) had seen a doctor about their pain. PLWH experiencing current pain had more depressive symptoms, poorer quality-of-life on all domains and greater functional impairment, regardless of age group. CONCLUSION: Even in the effective antiretroviral therapy era, pain remains common in PLWH and has a major impact on quality-of-life and associated healthcare and societal costs. Interventions are required to assist clinicians and PLWH to proactively manage pain.

AB - OBJECTIVE: We describe the prevalence of pain and its associations with healthcare resource utilization and quality-of-life. DESIGN: The POPPY Study recruited three cohorts: older people living with HIV (PLWH; ≥50 years, n = 699), younger demographically/lifestyle similar PLWH (less than 50 years, n = 374) and older demographically/lifestyle similar HIV-negative (≥50 years, n = 304) people from April 2013 to February 2016. METHODS: Current pain and pain-related healthcare use was collected via a self-reported questionnaire. Logistic regression assessed between-group differences in the prevalence of pain in the past month and current pain after controlling for potential confounders. Associations between current pain and healthcare resource use, reported joint problems, depressive symptoms, quality-of-life and functional status were assessed in PLWH using Mann-Whitney U and chi-squared tests. RESULTS: Pain in the past month was reported by 473 out of 676 (70.0%) older PLWH, 224 out of 357 (62.7%) younger PLWH and 188 out of 295 (63.7%) older HIV-negative controls (P = 0.03), with current pain reported in 330 (48.8%), 134 (37.5%) and 116 (39.3%), respectively (P = 0.0007). Older PLWH were more likely to experience current pain, even after adjustment for confounders. Of those with pain in the past month, 56 out of 412 (13.6%) had missed days of work or study due to pain, and 520 (59%) had seen a doctor about their pain. PLWH experiencing current pain had more depressive symptoms, poorer quality-of-life on all domains and greater functional impairment, regardless of age group. CONCLUSION: Even in the effective antiretroviral therapy era, pain remains common in PLWH and has a major impact on quality-of-life and associated healthcare and societal costs. Interventions are required to assist clinicians and PLWH to proactively manage pain.

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U2 - 10.1097/QAD.0000000000002021

DO - 10.1097/QAD.0000000000002021

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SN - 0269-9370

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JO - AIDS (London, England)

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ER -

Pain in people living with HIV and its association with healthcare resource use, well being and functional status

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