TY - JOUR
T1 - Pain-resolving microglia
AU - Sideris-Lampretsas, George
AU - Malcangio, Marzia
N1 - Funding Information:
We acknowledge funds from the European Union Horizon 2020research andinnovation programme“TOBeATPAIN” under Marie Skłodowska-Curie grant agreement 764860.
Funding Information:
We acknowledge funds from the European Union Horizon 2020 research and innovation programme ?TOBeATPAIN? under Marie Sk?odowska-Curie grant agreement 764860.
Publisher Copyright:
Copyright © 2022 The Authors
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Neuropathic pain after peripheral nerve damage is a lasting condition that generally persists even when the cause of damage disappears (1). The immune system is integral to the development of neuropathic pain: In the spinal cord, microglia-the central nervous system-resident macrophages-respond to neuronal activity and set up a positive feedback loop with neurons that promotes pain onset. Thus, disruption of microglia-neuron communication is being considered as a strategy to produce analgesia. On page 86 of this issue, Kohno et al. (2) describe a spinal cord-resident pool of microglia that emerges during pain maintenance and contributes to the resolution of neuropathic pain in mice. Microglial heterogeneity is a well-accepted concept that is underexplored in the context of chronic pain (3). The finding that spinal cord microglia acquire spatial and temporal transcriptional heterogeneity that affects pain could identify new therapeutic strategies to relieve pain.
AB - Neuropathic pain after peripheral nerve damage is a lasting condition that generally persists even when the cause of damage disappears (1). The immune system is integral to the development of neuropathic pain: In the spinal cord, microglia-the central nervous system-resident macrophages-respond to neuronal activity and set up a positive feedback loop with neurons that promotes pain onset. Thus, disruption of microglia-neuron communication is being considered as a strategy to produce analgesia. On page 86 of this issue, Kohno et al. (2) describe a spinal cord-resident pool of microglia that emerges during pain maintenance and contributes to the resolution of neuropathic pain in mice. Microglial heterogeneity is a well-accepted concept that is underexplored in the context of chronic pain (3). The finding that spinal cord microglia acquire spatial and temporal transcriptional heterogeneity that affects pain could identify new therapeutic strategies to relieve pain.
UR - http://www.scopus.com/inward/record.url?scp=85127375318&partnerID=8YFLogxK
U2 - 10.1126/science.abo5592
DO - 10.1126/science.abo5592
M3 - Article
C2 - 35357920
AN - SCOPUS:85127375318
SN - 0036-8075
VL - 376
SP - 33
EP - 34
JO - Science
JF - Science
IS - 6588
ER -
