King's College London

Research portal

Pain vulnerability: a neurobiological perspective

Research output: Contribution to journalLiterature reviewpeer-review

Original languageEnglish
Pages (from-to)192-200
Number of pages9
JournalNature Neuroscience
Volume17
Issue number2
Early online date28 Jan 2014
DOIs
Accepted/In press17 Dec 2013
E-pub ahead of print28 Jan 2014
PublishedFeb 2014

Documents

King's Authors

Abstract

There are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerability and resilience toward developing chronic pain. Particular focus will be given to genetic and epigenetic processes, priming effects on a cellular level, and alterations in brain networks concerned with reward, motivation/learning and descending modulatory control. Although research in this area is still in its infancy, a better understanding of how pain vulnerability emerges has the potential to help identify individuals at risk and may open up new therapeutic avenues.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454