PAK-dependent regulation of actin dynamics in breast cancer cells

Marianne Best, Madeline E. Gale, Claire M. Wells*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
89 Downloads (Pure)

Abstract

Metastatic Breast Cancer has a poor 25% survival rate and currently there are no clinical therapeutics which target metastasis. ‘Migrastatics’ are a new drug class which target migration pathway effector proteins in order to inhibit cancer cell invasion and metastasis. The p21-activated kinases (PAKs) are essential drivers of breast cancer cell migration and invasion through their regulation of actin cytoskeletal dynamics. Therefore, the PAKs present as attractive migrastatic candidates. Here we review how PAKs regulate distinct aspects of breast cancer actin dynamics focussing on cytoskeletal reorganisation, cell:matrix adhesion, actomyosin contractility and degradative invasion. Lastly, we discuss the introduction of PAK migrastatics into the well-honed breast cancer clinical pipeline.

Original languageEnglish
Article number106207
JournalInternational Journal of Biochemistry and Cell Biology
Volume146
Early online date11 Apr 2022
DOIs
Publication statusPublished - 31 May 2022

Keywords

  • Actin cytoskeletal dynamics
  • Breast cancer
  • Cell invasion
  • Metastasis
  • Migrastatics
  • p21-activated kinases

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