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Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors

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Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors. / Cozzitorto, Corinna; Spagnoli, Francesca Maria.

In: Current Topics in Developmental Biology, Vol. 132, 2019, p. 221-256.

Research output: Contribution to journalReview article

Harvard

Cozzitorto, C & Spagnoli, FM 2019, 'Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors', Current Topics in Developmental Biology, vol. 132, pp. 221-256. https://doi.org/10.1016/bs.ctdb.2018.12.005

APA

Cozzitorto, C., & Spagnoli, F. M. (2019). Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors. Current Topics in Developmental Biology, 132, 221-256. https://doi.org/10.1016/bs.ctdb.2018.12.005

Vancouver

Cozzitorto C, Spagnoli FM. Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors. Current Topics in Developmental Biology. 2019;132:221-256. https://doi.org/10.1016/bs.ctdb.2018.12.005

Author

Cozzitorto, Corinna ; Spagnoli, Francesca Maria. / Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors. In: Current Topics in Developmental Biology. 2019 ; Vol. 132. pp. 221-256.

Bibtex Download

@article{ca9583ace7474f65a6cf4515eb5155c2,
title = "Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors",
abstract = "During embryonic development, pancreatic epithelial cells engage in concomitant morphogenetic and fate specification events that will give rise to the final organ architecture and functions. Cues from the surrounding microenvironment are known to influence the behavior of epithelial progenitors and orchestrate these concomitant events throughout pancreas development. Nevertheless, the composition of the pancreatic microenvironment remains elusive; also, the interplay between components of the surrounding microenvironment and the epithelium is poorly characterized. We present here a comprehensive overview of the pancreatic microenvironment and what is known regarding distinct cell types, signaling molecules, ECM, that constitute it. We focus on the molecular circuits governing cell-cell interactions, which are at play in the developing pancreas, controlling pancreatic progenitor proliferation, morphogenesis, and differentiation. Finally, open questions and implication of future research in this field are discussed in the context of pancreatic diseases, such as diabetes and cancer, as well as therapeutic approaches for these diseases.",
author = "Corinna Cozzitorto and Spagnoli, {Francesca Maria}",
year = "2019",
doi = "10.1016/bs.ctdb.2018.12.005",
language = "English",
volume = "132",
pages = "221--256",
journal = "Current Topics in Developmental Biology",
issn = "0070-2153",
publisher = "ACADEMIC PRESS INC",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors

AU - Cozzitorto, Corinna

AU - Spagnoli, Francesca Maria

PY - 2019

Y1 - 2019

N2 - During embryonic development, pancreatic epithelial cells engage in concomitant morphogenetic and fate specification events that will give rise to the final organ architecture and functions. Cues from the surrounding microenvironment are known to influence the behavior of epithelial progenitors and orchestrate these concomitant events throughout pancreas development. Nevertheless, the composition of the pancreatic microenvironment remains elusive; also, the interplay between components of the surrounding microenvironment and the epithelium is poorly characterized. We present here a comprehensive overview of the pancreatic microenvironment and what is known regarding distinct cell types, signaling molecules, ECM, that constitute it. We focus on the molecular circuits governing cell-cell interactions, which are at play in the developing pancreas, controlling pancreatic progenitor proliferation, morphogenesis, and differentiation. Finally, open questions and implication of future research in this field are discussed in the context of pancreatic diseases, such as diabetes and cancer, as well as therapeutic approaches for these diseases.

AB - During embryonic development, pancreatic epithelial cells engage in concomitant morphogenetic and fate specification events that will give rise to the final organ architecture and functions. Cues from the surrounding microenvironment are known to influence the behavior of epithelial progenitors and orchestrate these concomitant events throughout pancreas development. Nevertheless, the composition of the pancreatic microenvironment remains elusive; also, the interplay between components of the surrounding microenvironment and the epithelium is poorly characterized. We present here a comprehensive overview of the pancreatic microenvironment and what is known regarding distinct cell types, signaling molecules, ECM, that constitute it. We focus on the molecular circuits governing cell-cell interactions, which are at play in the developing pancreas, controlling pancreatic progenitor proliferation, morphogenesis, and differentiation. Finally, open questions and implication of future research in this field are discussed in the context of pancreatic diseases, such as diabetes and cancer, as well as therapeutic approaches for these diseases.

UR - http://www.scopus.com/inward/record.url?scp=85059298592&partnerID=8YFLogxK

U2 - 10.1016/bs.ctdb.2018.12.005

DO - 10.1016/bs.ctdb.2018.12.005

M3 - Review article

VL - 132

SP - 221

EP - 256

JO - Current Topics in Developmental Biology

JF - Current Topics in Developmental Biology

SN - 0070-2153

ER -

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