Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming

Francesca Spagnoli*, Abigail Isaacson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Diabetes is a group of metabolic disorders, which results from insufficient functional pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells, or their death or de-differentiation as compensation for insulin resistance. The ability to reprogram cell types within close developmental proximity to β-cells offers a strategy to replenish β-cell mass and a future possible treatment of diabetes. Here, we review recent advances in the fields of pancreas development and lineage reprogramming. We also probe the possibility of using reprogrammed cells as an approach by which to further understand developmental mechanisms, in particular roadblocks to changing cell identity. Finally, we highlight fundamental challenges that need to be overcome to advance lineage reprogramming for generating pancreatic cells.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume70
Early online dateOct 2021
DOIs
Publication statusPublished - Oct 2021

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