Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming

TY - JOUR

T1 - Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming

AU - Spagnoli, Francesca

AU - Isaacson, Abigail

N1 - Funding Information: We apologize for the works that have not been cited due to limited space. We acknowledge the support of the Wellcome Trust PhD studentship to AI [grant number 222354/Z/21/Z ]. The FMS lab is supported by an EFSD Research Grant [grant number 1117775 ] and European Union’s Horizon 2020 research and innovation programme Pan3DP FET Open [grant Number 800981 ]. Funding Information: We apologize for the works that have not been cited due to limited space. We acknowledge the support of the Wellcome Trust PhD studentship to AI [grant number 222354/Z/21/Z]. The FMS lab is supported by an EFSD Research Grant [grant number 1117775] and European Union's Horizon 2020 research and innovation programme Pan3DP FET Open [grant Number 800981]. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/10

Y1 - 2021/10

N2 - Diabetes is a group of metabolic disorders, which results from insufficient functional pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells, or their death or de-differentiation as compensation for insulin resistance. The ability to reprogram cell types within close developmental proximity to β-cells offers a strategy to replenish β-cell mass and a future possible treatment of diabetes. Here, we review recent advances in the fields of pancreas development and lineage reprogramming. We also probe the possibility of using reprogrammed cells as an approach by which to further understand developmental mechanisms, in particular roadblocks to changing cell identity. Finally, we highlight fundamental challenges that need to be overcome to advance lineage reprogramming for generating pancreatic cells.

AB - Diabetes is a group of metabolic disorders, which results from insufficient functional pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells, or their death or de-differentiation as compensation for insulin resistance. The ability to reprogram cell types within close developmental proximity to β-cells offers a strategy to replenish β-cell mass and a future possible treatment of diabetes. Here, we review recent advances in the fields of pancreas development and lineage reprogramming. We also probe the possibility of using reprogrammed cells as an approach by which to further understand developmental mechanisms, in particular roadblocks to changing cell identity. Finally, we highlight fundamental challenges that need to be overcome to advance lineage reprogramming for generating pancreatic cells.

UR - http://www.scopus.com/inward/record.url?scp=85107091277&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2021.05.003

DO - 10.1016/j.gde.2021.05.003

M3 - Review article

SN - 0959-437X

VL - 70

SP - 32

EP - 39

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

ER -