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Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume70
Early online dateOct 2021
DOIs
E-pub ahead of printOct 2021
PublishedOct 2021

Bibliographical note

Funding Information: We apologize for the works that have not been cited due to limited space. We acknowledge the support of the Wellcome Trust PhD studentship to AI [grant number 222354/Z/21/Z ]. The FMS lab is supported by an EFSD Research Grant [grant number 1117775 ] and European Union’s Horizon 2020 research and innovation programme Pan3DP FET Open [grant Number 800981 ]. Funding Information: We apologize for the works that have not been cited due to limited space. We acknowledge the support of the Wellcome Trust PhD studentship to AI [grant number 222354/Z/21/Z]. The FMS lab is supported by an EFSD Research Grant [grant number 1117775] and European Union's Horizon 2020 research and innovation programme Pan3DP FET Open [grant Number 800981]. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Diabetes is a group of metabolic disorders, which results from insufficient functional pancreatic β-cell mass either due to the autoimmune destruction of insulin producing β-cells, or their death or de-differentiation as compensation for insulin resistance. The ability to reprogram cell types within close developmental proximity to β-cells offers a strategy to replenish β-cell mass and a future possible treatment of diabetes. Here, we review recent advances in the fields of pancreas development and lineage reprogramming. We also probe the possibility of using reprogrammed cells as an approach by which to further understand developmental mechanisms, in particular roadblocks to changing cell identity. Finally, we highlight fundamental challenges that need to be overcome to advance lineage reprogramming for generating pancreatic cells.

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